{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:42:11Z","timestamp":1761007331126,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI28071"],"award-info":[{"award-number":["AI28071"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>To evaluate whether P300 testing might serve as a screening modality for the early detection of HIV\u2010related neuropathology, we tested 26 HIV\u2010infected men (23 without neurologic symptoms, 2 with peripheral neuropathy, 1 with AIDS\u2010associated dementia) and 15 controls. Although they had no overt neurologic symptoms, the P300 latency was delayed or undetectable in 30% of patients without clinically evident neurologic disease. P300 latencies did not correlate with peripheral blood CD4 T\u2010cell count, serum quinolinic acid or p24 antigen levels, or the numbers of activated peripheral blood monocytes. Three individuals with abnormal P300 latencies had been HIV\u2010seropositive for \u2264 1 year, suggesting that delayed evoked responses detect early neurologic dysfunction. P300 responses do not predict imminent dementia. In only one previously asymptomatic individual with abnormal P300 waveforms have overt neurologic symptoms developed during a 2\u2010year followup. Extended longitudinal studies will be necessary to define the predictive value of P300 latencies in the development of AIDS\u2010related dementia. However, the sensitivity, quantitative nature, and speed of administration of this test suggest that it may be useful for identification of early neurologic involvement in HIV infection.<\/jats:p>","DOI":"10.1177\/019459989411000106","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:51:26Z","timestamp":1448434286000},"page":"53-59","source":"Crossref","is-referenced-by-count":3,"title":["Auditory p300 abnormalities and leukocyte activation in hiv infection"],"prefix":"10.1002","volume":"110","author":[{"given":"Holly H.","family":"Birdsall","sequence":"first","affiliation":[{"name":"Department of Immunology Research Laboratory Research Center for AIDS and HIV Infection University of Houston Houston Texas"},{"name":"Departments of Otorhinolaryngology University of Houston Houston Texas"},{"name":"Department of Microbiology and Immunology University of Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent N.","family":"Ozluoglu","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology University of Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry L.","family":"Lew","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology University of Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann","family":"Trial","sequence":"additional","affiliation":[{"name":"Department of Immunology Research Laboratory Research Center for AIDS and HIV Infection University of Houston Houston Texas"},{"name":"Department of Medicine Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denice P.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Speech Pathology University of Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha J.","family":"Wofford","sequence":"additional","affiliation":[{"name":"Department of Division of Audiology at the Veterans Affaris Medical Center University of Houston Houston Texas"},{"name":"Departments of Otorhinolaryngology University of Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Jerger","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology University of Houston Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger D.","family":"Rossen","sequence":"additional","affiliation":[{"name":"Department of Immunology Research Laboratory Research Center for AIDS and HIV Infection University of Houston Houston Texas"},{"name":"Department of Microbiology and Immunology University of Houston Houston Texas"},{"name":"Department of Medicine Baylor College of Medicine Houston 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