{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:41:13Z","timestamp":1761007273132,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Pol\u2010DC00133","5T32\u2010NS07084"],"award-info":[{"award-number":["Pol\u2010DC00133","5T32\u2010NS07084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p><jats:italic>Pseudomonas aeruginosa<\/jats:italic> was injected intranasally into four groups of chinchillas to determine if these bacteria can invade the middle ear by way of the eustachian tube. One group completed penicillin treatment of bilateral penumococcal otitis media (POM), and the second group started penicillin treatment of bilateral POM at the time of <jats:italic>P. aeruginosa<\/jats:italic> injection. A third group had no POM, but completed a course of penicillin treatment before <jats:italic>P. aeruginosa<\/jats:italic> injection, and a fourth group had no POM and received no penicillin. Middle ear susceptibility to nasally injected <jats:italic>P. aeruginosa<\/jats:italic> was significantly higher in animals with POM (61%) than in animals without POM (32%, <jats:italic>p<\/jats:italic> = 0.001). Forced eustachian tube opening pressures did not correlate with <jats:italic>P. aeruginosa<\/jats:italic> susceptibility. Thus, <jats:italic>P. aeruginosa<\/jats:italic>, the principle pathogen of chronic suppurative otitis media, can invade the middle ear by way of the eustachian tube, and acute otitis media predisposes to middle ear infection by <jats:italic>P. aeurginosa<\/jats:italic>.<\/jats:p>","DOI":"10.1177\/019459989411000114","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:51:26Z","timestamp":1448434286000},"page":"115-121","source":"Crossref","is-referenced-by-count":1,"title":["Acute otitis media increases middle ear susceptibility to nasal injection of <i>Pseudomonas Aeruginosa<\/i>"],"prefix":"10.1002","volume":"110","author":[{"given":"Patrick J.","family":"Antonelli","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology Otitis Media Research Center School of Medicine Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K.","family":"Juhn","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Otitis Media Research Center School of Medicine Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chap T.","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Biostatistics School of Public Health University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Scott","family":"Giebink","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Otitis Media Research Center School of Medicine Minneapolis Minnesota"},{"name":"Departments of Pediatrics Otitis Media Research Center School of Medicine Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01648935"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198603000-00013"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198604000-00017"},{"key":"e_1_2_1_5_1","first-page":"487","volume-title":"Pediatric Otolaryngology","author":"Bluestone CD","year":"1990"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100050404"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510005115X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200708"},{"key":"e_1_2_1_9_1","first-page":"219","article-title":"Experimental Pseudomonas aeruginosa otitis media induced by nasal inoculation: influence of acute otitis media","volume":"105","author":"Antonelli PJ","year":"1991","journal-title":"OTOLARYNGOL HEAD NECK SURG"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800070057007"},{"key":"e_1_2_1_11_1","first-page":"19","article-title":"Chinchilla animal model of chronic suppurative otitis media","volume":"131","author":"Kenna MA","year":"1988","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.41.3.913-920.1983"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894850941S204"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488409107569"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548709018477"},{"key":"e_1_2_1_16_1","first-page":"97","article-title":"Influence of amoxycillin and cefaclor on the colonization resistance of the oropharynx","volume":"39","author":"Van Saene HKF","year":"1983","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.2.279"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/134.6.595"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948109000119"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.36.3.1223-1228.1982"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.54.2.379-385.1986"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112787"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700402"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800140038006"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:38:50Z","timestamp":1760963930000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989411000114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1177\/019459989411000114"],"URL":"https:\/\/doi.org\/10.1177\/019459989411000114","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}