{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:55:51Z","timestamp":1762001751744,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p>Giant cell granuloma is a benign lesion that generally involves the mandible and maxilla. It may be locally aggressive and result in extensive tissue destruction in advanced cases. A retrospective analysis of giant cell granuloma during the Interval 1970 to 1990 revealed 18 cases of advanced disease, as defined by bone destruction and a greatest dimension of 2.0\u00a0cm or more. Epidemiologic factors, physical findings, Imaging studies, pathologic specimens, treatment modalities, and outcome were reviewed for each case. Eight lesions were treated by local excision and curettage, and 10 were treated by partial mandibulectomy. Five mandibular defects were reconstructed with lilac bone grafts and one with a free flap. Only one patient with maxillary giant cell granuloma who underwent curettage had regrowth of what is suspected to have been residual disease. Individualized treatment, tailoring the extent of resection to the extent of disease, provided excellent results.<\/jats:p>","DOI":"10.1177\/019459989411000411","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:52:37Z","timestamp":1448434357000},"page":"413-418","source":"Crossref","is-referenced-by-count":18,"title":["Advanced giant cell granuloma: A twenty\u2010year study"],"prefix":"10.1002","volume":"110","author":[{"given":"Eric M.","family":"Tallan","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry D.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas V.","family":"McCaffrey","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Krishnan","family":"Unni","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Lund","sequence":"additional","affiliation":[{"name":"Section of Oral and Maxillofacial Surgery Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1016\/0030-4220(53)90151-0"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1016\/0030-4220(59)90215-4"},{"key":"e_1_2_1_4_1","first-page":"523","article-title":"Conservative treatment of central giant cell granuloma of the mandible: report of a case with a 10\u2010year follow\u2010up","volume":"54","author":"Swanson AE","year":"1988","journal-title":"Can Dental Assoc J"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1016\/0030-4220(82)90297-3"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1097\/00006534-198603000-00030"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1177\/019459988709700514"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1093\/ajcp\/45.4.437"},{"key":"e_1_2_1_9_1","first-page":"606","article-title":"Oral giant cell granulomas. A clinical and histological study of 129\u00a0new cases","volume":"81","author":"Andersen L.","year":"1973","journal-title":"Acta Pathol Microbiol Scand"},{"key":"e_1_2_1_10_1","first-page":"705","article-title":"A destructive giant cell lesion of the mandible","volume":"31","author":"Curtis ML","year":"1973","journal-title":"J Oral Surg"},{"key":"e_1_2_1_11_1","first-page":"323","article-title":"Definitive treatment of recurring reparative central giant cell granuloma: a 10\u2010year follow\u2010up","volume":"52","author":"Lovely FW","year":"1986","journal-title":"Can Dental Assoc J"},{"key":"e_1_2_1_12_1","first-page":"558","volume-title":"Oral and maxillofacial surgery. Volume 2: oral surgery","author":"Gold L.","year":"1985"},{"volume-title":"Tumors and tumorous conditions of the bones and joints","year":"1958","author":"Jaffe HL","key":"e_1_2_1_13_1"},{"volume-title":"Oral surgery","year":"1963","author":"Thoma KH","key":"e_1_2_1_14_1"},{"key":"e_1_2_1_15_1","first-page":"395","volume-title":"Tumors of the head and neck: clinical and pathological considerations","author":"Batsakis JG","year":"1979"},{"key":"e_1_2_1_16_1","first-page":"75","article-title":"Malignant giant cell tumor of the mandible: report of case","volume":"17","author":"Hayward JR","year":"1959","journal-title":"J Oral Surg"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:53:21Z","timestamp":1760961201000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989411000411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1177\/019459989411000411"],"URL":"https:\/\/doi.org\/10.1177\/019459989411000411","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}