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Anaphylaxis may occur in a varlety of circumstances: however, when it occurs as the result of Immunotherapy, it is of great concern to the practicing allergist. When describing or reporting anaphylaxis relating to Immunotherapy, most allergists speak in terms of the types of reactions, local vs. systemic. Germane to this discussion is the use of the term <jats:italic>systemic reaction<\/jats:italic>, which can mean anything from mild allergy symptoms resulting from an allergy injection to bradycardia and hypotension (shock). In this article we report serious or significant systemic reactions, which are characterized by any of the following symptoms: urticaria, sneezing or nasal obstruction, throat tightness or congestion, wheezing, and shock (bradycardta or hypotension). There were no fatalities reported from the survey group. The overall reaction rate was 0.3%.<\/jats:p>","DOI":"10.1177\/019459989411000603","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T04:13:49Z","timestamp":1485576829000},"page":"487-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Systemic reactions to immunotherapy: The american academy of otolaryngic allergy morbidity and mortality survey"],"prefix":"10.1002","volume":"110","author":[{"given":"Paul R.","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Otolaryngology University of Missouri\u2014Columbia Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"James L.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology University of Missouri\u2014Columbia Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore T.","family":"Benke","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Otolaryngology University of Missouri\u2014Columbia Columbia Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold S.","family":"Rapoport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1016\/S0091-6749(87)80164-1"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1016\/0021-8707(57)90130-2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1016\/0091-6749(86)90385-4"},{"key":"e_1_2_1_5_1","first-page":"119","article-title":"Studies in specific hypersensitivity III. 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