{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:36:42Z","timestamp":1781332602054,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":8022,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To learn about the effects of cranial base surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN<\/jats:title><jats:p>Cohort study with a mean follow\u2010up of 30\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Population\u2010based.<\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS<\/jats:title><jats:p>A consecutive sample of 183 patients who underwent cranial base surgery; 118 patients had malignant skull base tumors, the majority of which were previously treated; 50 had benign tumors; 9 had congenital malformations of the skull base; 3 had inflammatory lesions, and 3 had traumatic defects of the skull base.<\/jats:p><\/jats:sec><jats:sec><jats:title>MAIN OUTCOME MEASURES<\/jats:title><jats:p>Disease\u2010free Interval, overall survival, and rate of complications and functional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>INTERVENTION<\/jats:title><jats:p>Cranial base surgery was followed by radiotherapy (In previously untreated patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After completion of follow\u2010up (mean, 30\u00a0months), 30 (25.4%) patients had died of their malignant tumors and 8 (6.8%) had died of other causes. One patient (0.84%) was lost to follow\u2010up. The overall cancer survival rate without regard to histologic type was 67% (63% with no evidence of disease). Among the patients who were treated for benign neoplasm, 72% had no evidence of disease at a mean follow\u2010up of 39\u00a0months. The group of patients with congenital malformations and inflammatory and traumatic lesions demonstrated successful correction of their presurgical problem with skull base surgery. One patient (who had invasive aspergillosis) died of disease. The overall surgical\u2010medical mortality rate was 2%; the complication rate was 33%, and the Kamofsky performance score was improved or unchanged after surgery in 83% of patients. The average duration of surgery, number of blood transfusions used, and length of the hospital stay were 10 hours, 3 units, and 15\u00a0days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Cranial base surgery is a valid surgical technique for treatment of cranial base afflictions. In this study It was found to be beneficial In controlling benign and malignant disease and to be the treatment of choice for selected congenital malformations, trauma, and inflammatory lesions.<\/jats:p><\/jats:sec>","DOI":"10.1177\/019459989411000611","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T04:13:49Z","timestamp":1485576829000},"page":"539-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Cranial base surgery: Results in 183 patients"],"prefix":"10.1002","volume":"110","author":[{"given":"Iva P.","family":"Janecka","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine Duquesne University Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandranath","family":"Sen","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center Duquesne University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laligam N.","family":"Sekhar","sequence":"additional","affiliation":[{"name":"George Washington University Medical Center Duquesne University Washington, D.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Ramasastry","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Duquesne University Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh D.","family":"Curtin","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Duquesne University Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Leon","family":"Barnes","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Duquesne University Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science Duquesne University Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401977"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300312"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-9183-5_31"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.4.0578"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.2.0198"},{"key":"e_1_2_1_7_1","first-page":"157","volume-title":"Surgery of cranial base tumors","author":"Janecka IP","year":"1993"},{"key":"e_1_2_1_8_1","first-page":"193","article-title":"Transfacial approaches to the clivus and upper cervical spine","volume":"3","author":"Janecka IP","year":"1993","journal-title":"Neurosurg Operative Atlas"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199303000-00009"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198308000-00016"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L"},{"key":"e_1_2_1_12_1","first-page":"36","article-title":"Medicine, money, and mathematics","volume":"77","author":"Eddy DM","year":"1992","journal-title":"ACS Bull"},{"key":"e_1_2_1_13_1","first-page":"945","volume-title":"Head and neck cancer","author":"Janecka IP","year":"1993"},{"key":"e_1_2_1_14_1","article-title":"Treatment of paranasal sinus cancer with cranial base surgery: Results","author":"Janecka IP","journal-title":"Laryngoscope"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198902000-00005"},{"key":"e_1_2_1_16_1","article-title":"Risk factors for complications in clean\u2010contaminated head and neck surgical procedures","author":"Girod DA","journal-title":"Head and Neck"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1060574"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:58:18Z","timestamp":1760965098000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989411000611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1177\/019459989411000611"],"URL":"https:\/\/doi.org\/10.1177\/019459989411000611","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]},"assertion":[{"value":"1993-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}