{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:31:04Z","timestamp":1761823864996,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":8022,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>Wound healing research has produced some startling discoveries during the past decade. Foremost among these is the observation that cutaneous wounds created and healed <jats:italic>in utero<\/jats:italic> are histologically indistinguishable from intact, unwounded tissue. Observers have documented that the acute inflammatory response and endogenous immunoglobullns that characterize healing in human beings after birth are absent in the fetal wound. Determination of the cellular and biochemical differences between fetal and postdelivery wound healing offers the promise of Improved control over the process of tissue repair. Another promise of fetal wound healing research is the option of <jats:italic>in utero<\/jats:italic> repair of defects such as cieft lip and palate. We review what is known at present about fetal wound healing.<\/jats:p>","DOI":"10.1177\/019459989411000612","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T04:13:49Z","timestamp":1485576829000},"page":"547-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fetal wound healing"],"prefix":"10.1002","volume":"110","author":[{"suffix":"III","given":"H. Bryan","family":"Neel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Harner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Broker","sequence":"additional","affiliation":[{"name":"Center for Facial Plastic Surgery Thomas Jefferson University Hospital Department of Otolaryngology\u2014Head and Neck Surgery Jefferson Medical College Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Reiter","sequence":"additional","affiliation":[{"name":"Center for Facial Plastic Surgery Thomas Jefferson University Hospital Department of Otolaryngology\u2014Head and Neck Surgery Jefferson Medical College Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"299","article-title":"Fetal wound healing","volume":"176","author":"Dostal GH","year":"1993","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_3_1","first-page":"1","volume-title":"Wound repair","author":"Peacock EE","year":"1984"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107007"},{"key":"e_1_2_1_5_1","first-page":"78","article-title":"Augmentation of wound tensile strength in rats by induction of inflammation with autogenous blood","volume":"83","author":"Myers B","year":"1978","journal-title":"Surgery"},{"key":"e_1_2_1_6_1","first-page":"1","article-title":"Biochemical basis of tensile strength in wound healing","author":"Viljanto J","year":"1965","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.4.719"},{"key":"e_1_2_1_8_1","first-page":"441","article-title":"Scarless wound healing in the mammalian fetus","volume":"174","author":"Mast BA","year":"1992","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80210-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199004000-00001"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199104000-00032"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(71)90373-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(87)80117-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860240085029"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80537-8"},{"key":"e_1_2_1_16_1","first-page":"613","article-title":"Fetal wounds do not contract in utero","volume":"40","author":"Krummel TM","year":"1989","journal-title":"Surg Forum"},{"key":"e_1_2_1_17_1","first-page":"639","article-title":"Adult skin in the fetal environment heals with scar formation","volume":"41","author":"Longaker MT","year":"1990","journal-title":"Surg Forum"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411000612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:58:03Z","timestamp":1760965083000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989411000612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1177\/019459989411000612"],"URL":"https:\/\/doi.org\/10.1177\/019459989411000612","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1994,6]]},"assertion":[{"value":"2016-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}