{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:18:41Z","timestamp":1774916321318,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>Obstructive sleep apnea syndrome is a complex disorder that has been associated with a variety of abnormalities of the upper airway, including tonsil and adenoid hypertrophy, nasal obstruction, retrognathia, and macroglossia. The cause of the airway obstruction in acromegaly is believed to be related to osseous and soft\u2010tissue changes surrounding the upper airway, which lead to narrowing and subsequent collapse during sleep. We describe the results of treatment in seven patients with both sleep apnea and acromegaly. Four patients were treated by transsphenoidal hypophysectomy alone with a resolution of sleep apnea syndrome. One underwent hypophysectomy followed by postoperative radiation therapy, which reduced his apnea. Three patients underwent unsuccessful uvulopalatopharyngoplasty. Successful treatment of the primary disorder, in this case acromegaly, resulted in improved breathing during sleep in five patients. This series would suggest that acromegalic patients with sleep apnea should be treated for their pituitary tumor to reduce growth hormone before consideration of surgery to enlarge or bypass the upper airway.<\/jats:p>","DOI":"10.1177\/019459989411100107","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T06:53:21Z","timestamp":1448434401000},"page":"25-30","source":"Crossref","is-referenced-by-count":32,"title":["Obstructive Sleep Apnea Syndrome and Acromegaly"],"prefix":"10.1002","volume":"111","author":[{"given":"Samuel A.","family":"Mickelson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Henry Ford Hospital Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon D.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center Henry Ford Hospital Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack P.","family":"Rock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Henry Ford Hospital Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent A.","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Boston Eye and Ear Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Friduss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.27.020176.002341"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-11-200606060-00004"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.4.519"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(18)30537-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1985.00360050121021"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-1-18"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90477-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6218.894"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275587"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb02947.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-7-527"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000125737"},{"key":"e_1_2_1_14_1","first-page":"96","article-title":"Abnormal orbicularis oculi reflex in sleep apnea secondary to acromegaly. Evidence of pontomedullary dysfunction in sleep apnea syndrome","volume":"24","author":"Gadoth N","year":"1988","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198801000-00010"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91405-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(89)80089-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.64.758.945"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411100107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989411100107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:23:22Z","timestamp":1760955802000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989411100107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1177\/019459989411100107"],"URL":"https:\/\/doi.org\/10.1177\/019459989411100107","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}