{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:00:36Z","timestamp":1762113636849,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":7900,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008189","name":"Deafness Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>A rabbit model was developed to simulate the effects of Ischemia that may occur during surgical removal of tumors Involving the cerebellopontine angle or internal auditory canal. Specifically, the internal auditory artery was visualized through a posterior craniotomy and mechanically compressed for repetitive 1\u2010minute intervals with a micromanipulator\u2010controlled glass pipet terminating in a smooth bead. The 2f<jats:sub>1<\/jats:sub>\u2010f<jats:sub>2<\/jats:sub> distortion\u2010product otoacoustic emissions were used to monitor the susceptibility of cochlear function to compressive effects. Distortion\u2010product otoacoustic emissions were measured during discrete preblock, block, and postblock periods to determine the time course of distortion\u2010product otoacoustic emission reduction and its return to baseline levels after rapid obstruction and resumption, respectively, of the cochlear vascular supply. Comparisons during these times indicated that preblock distortion\u2010product otoacoustic emission levels were very stable, often varying by less than 1\u00a0dB. Additionally, distortion\u2010product otoacoustic emissions were very sensitive to brief vascular occlusions in that, within approximately 25\u00a0seconds of blockage onset, emission levels at all frequencies decreased at rates of about \u2212 1.5\u00a0dB\/second. On alleviation of the occlusion, distortion\u2010product otoacoustic emissions rapidly and completely returned to preblock levels with a delay of about 4\u00a0seconds and recovery slopes of about 10.5\u00a0dB\/second. A notable finding in some animals was that early and reproducible variations in distortion\u2010product otoacoustic emission levels occurred within 5 to 8\u00a0seconds of internal auditory artery compression. When present, these transitory changes on distortion\u2010product otoacoustic emission levels acted as early warning signs for vascular compromise of cochlear function.<\/jats:p>","DOI":"10.1177\/019459989411100404","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:52:48Z","timestamp":1499907168000},"page":"407-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["First Place \u2014 Resident Clinical Science Award 1994: Early Effects of Cerebellopontine Angle Compression on Rabbit Distortion\u2010Product Otoacoustic Emissions: A Model for Monitoring Cochlear Function during Acoustic Neuroma Surgery"],"prefix":"10.1002","volume":"111","author":[{"given":"Michael P.","family":"Widick","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Miami Ear Institute Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred 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of vascular compromise on rabbit DPOAEs: Implications for cerebellopontine\u2010angle surgery","volume":"17","author":"Telischi FF","year":"1994","journal-title":"Assoc Res Otolaryngol Abstr"}],"container-title":["Otolaryngology\u2013Head and Neck 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