{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:02:27Z","timestamp":1760954547536,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":7138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p>In 1978 an epidemiologic study exploring the health consequences of nasopharyngeal radium irradiation among individuals treated for adenoid enlargement in Washington County, Maryland, found an excess risk of brain tumors and a deficit of female breast cancers. The study population included all persons first seen at the Washington County Clinic for the Prevention of Deafness in Children from 1940 to January 1, 1960. We will continue the follow\u2010up of irradiated and nonirradiated patients to (1) assess the risk of brain tumors and other neoplasms of the head and neck developing during a 40\u2010year period, (2) assess hormone\u2010related disorders resulting from irradiation of the pituitary gland, and (3) compare cancer incidence and mortality rates among exposed and nonexposed groups. Of the 2135 persons eligible for this study, 93.5% have been traced, and 90% have replied to a mailed questionnaire that elicits information on demographic characteristics, reproductive and medical history, infertility, and other sources of radiation exposure. Information on cancer incidence and mortality is being obtained from the Washington County Cancer Registry and death certificate flies from Washington County and the Social Security Administration. Statistical methods to be used in the data analysis include standardized mortality ratios, standardized cancer incidence ratios, and Kaplan\u2010Meier survival analysis.<\/jats:p>","DOI":"10.1177\/019459989611500509","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T23:50:22Z","timestamp":1499903422000},"page":"415-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Follow\u2010Up Study of Childhood Nasopharyngeal Radium Irradiation in Washington County, Maryland"],"prefix":"10.1002","volume":"115","author":[{"given":"Hsin\u2010Chieh","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Hygiene and Public Health Johns Hopkins University Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve M.","family":"Matanoski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Hygiene and Public Health Johns Hopkins University Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George W.","family":"Comstock","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Hygiene and Public Health Johns Hopkins University Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348944905800401"},{"key":"e_1_2_1_3_1","first-page":"3","article-title":"Neoplasms following childhood radium irradiation of the nasopharynx","volume":"68","author":"Sandler DP","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1976.10667184"},{"key":"e_1_2_1_5_1","first-page":"167","volume-title":"Late biological effects of ionizing radiation","author":"Colman M","year":"1978"},{"key":"e_1_2_1_6_1","first-page":"139","volume-title":"\u201cRadiation carcinogenesis: epidemiology and biological significance","author":"Ron E","year":"1984"},{"key":"e_1_2_1_7_1","first-page":"364","article-title":"Endocrine complications after radiotherapy for tumors of the head and neck","volume":"109","author":"Samaan NA","year":"1987","journal-title":"J Lab Clin Med"},{"issue":"262","key":"e_1_2_1_8_1","first-page":"145","article-title":"Hypopituitarism following external radiotherapy for pituitary tumors in adults","volume":"70","author":"Littley MD","year":"1989","journal-title":"QJM"},{"key":"e_1_2_1_9_1","first-page":"165","article-title":"Effects of cranial irradiation on hypothalamic\u2010pituitary function: A 5\u2010year longitudinal study in patients with nasopharyngeal carcinoma","volume":"78","author":"Lam KS","year":"1991","journal-title":"QJM"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301143280203"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989611500509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/019459989611500509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:45:54Z","timestamp":1760949954000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/019459989611500509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1177\/019459989611500509"],"URL":"https:\/\/doi.org\/10.1177\/019459989611500509","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1996,11]]},"assertion":[{"value":"1996-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}