{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:26:40Z","timestamp":1761006400997,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":7138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p>The pathogenesis of otitis media with effusion is still under debate, but allergic sensitization has been suggested in some cases. We investigated whether nasal cytology may indicate an allergic pathogenesis for otitis media with effusion. Atopic symptoms, results of skin prick tests to common aeroallergens, and nasal cytology by nasal scraping were evaluated in 40 children with current otitis media with effusion and compared with findings in a group of 40 healthy children. The presence of nasal eosinophils was significantly more frequent in children with otitis media with effusion than in the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). Nasal eosinophils were significantly associated with both allergic rhinitis (<jats:italic>p<\/jats:italic> &lt; 0.001) and positive skin prick test results (<jats:italic>p<\/jats:italic> &lt; 0.001). Allergic rhinitis with nasal eosinophilla was found in six children of the study group and in one child of the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). Our data suggest that nasal allergic Inflammation may play a role in a subset of patients with otitis media with effusion. Therefore the possibility of allergic sensitization must always be considered in patients with serous otitis media.<\/jats:p>","DOI":"10.1177\/019459989611500517","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T23:50:22Z","timestamp":1499903422000},"page":"454-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Nasal Eosinophils in Children with Otitis Media with Effusion"],"prefix":"10.1002","volume":"115","author":[{"given":"Carlo","family":"Caffarelli","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cavagni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Savini","sequence":"additional","affiliation":[{"name":"Head Center for the Study of Otitis Media with Effusion Tabiano Terme Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Piacentini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92501-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900315"},{"key":"e_1_2_1_4_1","first-page":"66","article-title":"The role of IgE mediated hypersensitivity in recurrent otitis media with effusion","volume":"5","author":"Bernstein JM","year":"1983","journal-title":"Am J Otol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988509300508"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800100050004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90690-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1975.00780340010003"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947408300316"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90019-1"},{"issue":"10","key":"e_1_2_1_11_1","first-page":"27","article-title":"Skin tests used in type I allergy testing. Position paper","volume":"44","author":"Dreborg S","year":"1989","journal-title":"Allergy"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90384-2"},{"key":"e_1_2_1_13_1","first-page":"117","volume-title":"Rhinitis. 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