{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:04Z","timestamp":1761007444228,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":6566,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>The monoclonal antibody 44\u20103A6 detects a cell\u2010surface protein that has been shown to be a useful marker in distinguishing adenocarcinomas from other histologic tumor types in a variety of tissues. The objective of this study was to determine whether 44\u20103A6 could be used as a tool in the classification of salivary gland neoplasms. These complex tumors share overlapping pathologic features but distinct clinical outcomes. This study used 44\u20133A6 to immunohistochemically describe the pattern and frequency of this antigen in salivary gland neoplasms. Formalin\u2010fixed, paraffin\u2010embedded tissue sections of 22 benign and 26\u00a0malignant salivary tumors were evaluated. The patient population consisted of 25 (52.1%) women and 23 (47.9%) men selected from archival pathology files to reflect a range of salivary gland diseases. Normal surrounding salivary glands were found to have intense focal staining almost exclusively localized to ductal luminal cells. There was little staining of either myoepithelial or acinar cells. A wide spectrum of expression was found between and within tumor types, but a trend toward more expression of this antigen with decreasing differentiation was seen. A significant increase in staining was also seen in those tumors with ductal differentiation (<jats:italic>n<\/jats:italic> = 41) as opposed to those with predominantly acinar (i.e., acinic cell carcinoma) or myoepithelial (i.e., myoepithelioma; <jats:italic>n<\/jats:italic> = 8) differentiation (2.6 vs. 1.3, <jats:italic>p<\/jats:italic> &lt; 0.05). No correlation was found between staining intensity and facial paralysis, pain, skin involvement, TNM stage, residual disease, or disease\u2010free or total survival. Therefore this antigen appears to designate a duct luminal phenotype in normal and neoplastic salivary tissues. (Otolaryngol Head Neck Surg 1998;118:603\u20139.)<\/jats:p>","DOI":"10.1177\/019459989811800507","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T16:43:20Z","timestamp":1291999400000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of the Adenocarcinoma\u2010Related Antigen Recognized by Monoclonal Antibody 44\u20103A6\u00a0in Salivary Gland Neoplasias"],"prefix":"10.1002","volume":"118","author":[{"given":"Brandon G.","family":"Bentz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Robert H. Lurie Cancer Center VA Lakeside Medical Center, and Northwestern University Medical School Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"G. Kenneth","family":"Haines","sequence":"additional","affiliation":[{"name":"Department of Pathology Robert H. Lurie Cancer Center VA Lakeside Medical Center, and Northwestern University Medical School Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed S.","family":"Vonschlegell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Robert H. Lurie Cancer Center VA Lakeside Medical Center, and Northwestern University Medical School Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Elseth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Robert H. Lurie Cancer Center VA Lakeside Medical Center, and Northwestern University Medical School Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Robert H. Lurie Cancer Center VA Lakeside Medical Center, and Northwestern University Medical School Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Radosevich","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Robert H. 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