{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:49:19Z","timestamp":1777499359601,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>To investigate the differentiation stage of tumor-infiltrating lymphocytes in thymoma tissue, we performed Southern blot analysis of T-cell receptor beta and gamma genes in thymomas resected from 19 patients. At the same time, we conducted flow cytometric analysis of T-cell surface markers and examined the clinicopathological features of the thymomas. We found that the incidence of T-cell receptor gamma gene rearrangement was significantly higher in Masaoka stage I thymomas (11 of 12 cases) than in stage II or III invasive thymomas (3 of 7 cases). Moreover, gamma gene rearrangement was observed in all 10 type AB and B1 thymoma specimens and in 4 of 6 type B2 thymoma specimens. The 2 specimens of type B3 thymomas, which were classified as stage III, showed neither gamma nor beta gene arrangement and were single-positive for CD4 or CD8. Six thymoma specimens that showed beta gene rearrangement expressed both CD4 and CD8. In conclusion, thymomas have the capability of T-lineage cell differentiation, except for a subset of invasive thymomas with malignant characteristics.<\/jats:p>","DOI":"10.1177\/021849230501300211","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T09:37:22Z","timestamp":1367833042000},"page":"149-152","source":"Crossref","is-referenced-by-count":1,"title":["Rearrangement of T-Cell Receptor Beta and Gamma Genes in Thymoma"],"prefix":"10.1177","volume":"13","author":[{"given":"Jun","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriho","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fukami","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Takamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"bibr1-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198612000-00005"},{"key":"bibr2-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60157-6"},{"key":"bibr3-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R"},{"key":"bibr4-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"bibr5-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00523-6"},{"key":"bibr6-021849230501300211","volume-title":"Atlas of tumor pathology, 3rd series, fasc","volume":"21","author":"Shimosato Y","year":"1997"},{"key":"bibr7-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37426-4"},{"key":"bibr8-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(92)90027-L"},{"key":"bibr9-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1007\/BF03217944"},{"key":"bibr10-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1038\/313647a0"},{"key":"bibr11-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90186-O"},{"key":"bibr12-021849230501300211","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.3.262"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/021849230501300211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/021849230501300211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/021849230501300211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:12:11Z","timestamp":1777389131000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/021849230501300211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1177\/021849230501300211"],"URL":"https:\/\/doi.org\/10.1177\/021849230501300211","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}