{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:58:01Z","timestamp":1777499881031,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Between January 2000 and June 2003, 70 patients (63 men and 7 women) with acute-on-chronic lower limb vascular occlusion underwent thrombolysis with 1 million units of urokinase. Forty-eight patients had unilateral and 22 had bilateral involvement; 9 had gangrenous changes. The mean age was 47 \u00b1 9 years, 73% were smokers, and 13% had diabetes. The definition of a good response was either return of distal pulses or a warm limb and relief of pain at rest. Fifty-three (76%) patients (including 5 with gangrenous changes) had symptomatic improvement with thrombolysis (group 1), and 17 (24%) did not respond (group 2). All 70 patients (including 7 who later required amputation) underwent surgical intervention with a polytetrafluoroethylene interposition graft or arterioplasty. A good response to surgical treatment was found in significantly more patients (49\/53, 92%) in group 1 compared to group 2 (7\/17, 41%). Claudication distance after 6 months of follow-up improved in a significantly higher percentage of patients in group 1 (85%) than group 2 (38%). Preoperative thrombolysis improved the outcome and predicted the result of arterial surgery.<\/jats:p>","DOI":"10.1177\/021849230701500509","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T09:37:22Z","timestamp":1367833042000},"page":"405-407","source":"Crossref","is-referenced-by-count":2,"title":["Urokinase Thrombolysis in Acute-on-Chronic Vascular Occlusion of Lower Limb"],"prefix":"10.1177","volume":"15","author":[{"given":"Chandra P","family":"Shrivastava","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, SMS Medical College & Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Devgarha","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, SMS Medical College & Hospital, Jaipur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"bibr1-021849230701500509","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198938050-00006"},{"key":"bibr2-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199806)44:2<159::AID-CCD8>3.0.CO;2-5"},{"key":"bibr3-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512193132501"},{"key":"bibr4-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205273062105"},{"key":"bibr5-021849230701500509","first-page":"41","volume":"124","author":"Byrne D","year":"1997","journal-title":"Va Med Q"},{"key":"bibr6-021849230701500509","doi-asserted-by":"publisher","DOI":"10.2174\/1568006043336113"},{"key":"bibr7-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-001-0318-y"},{"key":"bibr8-021849230701500509","first-page":"325","volume":"6","author":"Muller-Lung U","year":"1996","journal-title":"Aktuelle Radiol"},{"key":"bibr9-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00129-8"},{"key":"bibr10-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1117"},{"key":"bibr11-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00135-X"},{"key":"bibr12-021849230701500509","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381603"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/021849230701500509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/021849230701500509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/021849230701500509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:13:22Z","timestamp":1777389202000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/021849230701500509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1177\/021849230701500509"],"URL":"https:\/\/doi.org\/10.1177\/021849230701500509","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}