{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:02:25Z","timestamp":1777500145771,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>\n                    Homocysteinemia is a risk factor for cardiovascular diseases. Folic acid combined with vitamins B\n                    <jats:sub>6<\/jats:sub>\n                    and B\n                    <jats:sub>12<\/jats:sub>\n                    is effective in lowering homocysteine levels. This randomized placebo-controlled study was designed to determine the effect of a folic acid-based supplement on secondary prevention of clinical events in non-ST-segment elevation acute coronary syndromes. The study comprised 240 patients with either unstable angina or non-ST-elevation myocardial infarction in the previous 2 weeks who were randomized to a folate group ( n = 116) or a placebo group ( n = 124). The folate group received 1 mg folic acid, 400 \u03bcg vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    , and 10 mg vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    daily. Clinical outcomes within 6 months were assessed. The composite endpoint of death, nonfatal acute coronary syndrome, and serious re-hospitalization was significantly higher in the folate group; serious re-hospitalization alone was significantly higher in this group. Advanced age and diabetes increased susceptibility to the composite outcome. Folic acid-based supplementation is not beneficial and may even be harmful in the secondary prevention of cardiovascular events in patients with unstable angina and non-ST-elevation myocardial infarction. Further studies on the safety of such supplements are suggested. Controlled Clinical Trials Registry no. ISRCTN30249553.\n                  <\/jats:p>","DOI":"10.1177\/0218492309102494","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T09:37:22Z","timestamp":1367833042000},"page":"13-21","source":"Crossref","is-referenced-by-count":25,"title":["Folic Acid-Based Intervention in Non-ST Elevation Acute Coronary Syndromes"],"prefix":"10.1177","volume":"17","author":[{"given":"Marcelo Severino B","family":"Imasa","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of the Philippines College of Medicine, Manila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil T","family":"Gomez","sequence":"additional","affiliation":[{"name":"Philippine Heart Center, Quezon City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Jose B","family":"Nevado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of the Philippines College of Medicine, Manila"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"bibr1-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.59"},{"key":"bibr2-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2015"},{"key":"bibr3-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.12.2922"},{"key":"bibr4-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.18.1848"},{"key":"bibr5-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7135.894"},{"key":"bibr6-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3161"},{"key":"bibr7-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.8.973"},{"key":"bibr8-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032845"},{"key":"bibr9-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"bibr10-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"},{"key":"bibr11-0218492309102494","first-page":"108","volume":"9","author":"Namazi MH","year":"2006","journal-title":"Arch Iran Med"},{"key":"bibr12-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.5.565"},{"key":"bibr13-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.22.2720"},{"key":"bibr14-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.22.2557"},{"key":"bibr15-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2002001100008"},{"key":"bibr16-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1159\/000099050"},{"key":"bibr17-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707243370403"},{"key":"bibr18-0218492309102494","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1161\/01.CIR.0000016359.94919.16","volume":"105","author":"Januzzi JL","year":"2002","journal-title":"Circulation"},{"key":"bibr19-0218492309102494","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00809-3"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492309102494","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0218492309102494","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492309102494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:14:00Z","timestamp":1777389240000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0218492309102494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1177\/0218492309102494"],"URL":"https:\/\/doi.org\/10.1177\/0218492309102494","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}