{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:08:10Z","timestamp":1777525690801,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Background: valve-associated complications challenge the quality of life and longevity after heart valve replacement. Inappropriate healing may be a contributing factor.<\/jats:p>\n                  <jats:p>Objective: to evaluate a new design mechanical heart valve in an animal model.<\/jats:p>\n                  <jats:p>Methods and results: the new valve was fabricated by substituting the sewing ring with an inbuilt suture ridge and an overlying fabric flap. It improved the effective orifice area. Animal experiments were performed on pigs to compare this valve with standard valve models. The animals were kept on dual antiplatelet drugs. Six of the 8 test animals survived the observation period of 140 days compared to 2 of the 6 controls. Among the test valves, one had thrombosis and 3 had significant tissue hyperplasia, whereas 5 control valves had thrombosis associated with significant tissue hyperplasia. Three test valves had paravalvular defects compared to none in the control group. Histology showed good tissue incorporation of the fabric flap of the test valves, whereas the control valves had tissue infiltration limited to the peripheral fabric layer of the sewing ring.<\/jats:p>\n                  <jats:p>Conclusion: the new valve has improved effective orifice area, and the animal study showed better survival, good healing, and a lower incidence of thrombosis and tissue hyperplasia.<\/jats:p>","DOI":"10.1177\/0218492312438741","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T09:37:22Z","timestamp":1367833042000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A new concept in the sewing rings for mechanical heart valves"],"prefix":"10.1177","volume":"20","author":[{"given":"Mathew V","family":"Kurian","sequence":"first","affiliation":[{"name":"Madras Medical Mission, Chennai, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payanam R","family":"Umasankar","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute of Medical Sciences and Technology, Thiruvananthapuram, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arumugam","family":"Sabareeswaran","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute of Medical Sciences and Technology, Thiruvananthapuram, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin J","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute of Medical Sciences and Technology, Thiruvananthapuram, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayakumar","family":"Subban","sequence":"additional","affiliation":[{"name":"Madras Medical Mission, Chennai, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew K","family":"Joseph","sequence":"additional","affiliation":[{"name":"Kizhakkethottam, Bharananganam, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"bibr1-0218492312438741","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.09.002"},{"key":"bibr2-0218492312438741","first-page":"448","volume":"5","author":"Bhuvaneshwar GS","year":"1996","journal-title":"J Heart Valve Dis"},{"key":"bibr3-0218492312438741","first-page":"619","volume":"10","author":"Sankarkumar R","year":"2001","journal-title":"J Heart Valve Dis"},{"key":"bibr4-0218492312438741","unstructured":"Kurian MV, Sabareeswaran A, Kanchanamala M, Balachandran S, Mogileswari D, Subban V. The role of sewing ring in tissue healing\u2014a pathological study of explanted mechanical heart valves.\n                      J Heart Valve Dis\n                      (accepted for publication)."},{"key":"bibr5-0218492312438741","first-page":"393","volume-title":"Valvular Heart Disease","author":"Thai HM","year":"2000","edition":"3"},{"key":"bibr6-0218492312438741","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608083350607"},{"key":"bibr7-0218492312438741","first-page":"483","volume-title":"Kirklin\/Barratt-Boyes Cardiac Surgery","volume":"1","author":"Kouchoukos NT","year":"2003","edition":"3"},{"key":"bibr8-0218492312438741","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)01391-4"},{"key":"bibr9-0218492312438741","doi-asserted-by":"crossref","unstructured":"Schoen FJ. Approach to the analysis of cardiac valve prostheses as surgical pathology or autopsy specimens. Cardiovasc Pathol 1995;4:241\u201355. 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