{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:57:22Z","timestamp":1785391042228,"version":"3.55.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Objective: To assess the impact of pre-procedural remote ischemic preconditioning on the incidence of myocardial complications following percutaneous coronary intervention.<\/jats:p>\n                  <jats:p>Background: Ischemic preconditioning of a remote vascular territory improves the subsequent ischemic tolerance of distant organs.<\/jats:p>\n                  <jats:p>Method: The Myocardial Event Reduction with Ischemic Preconditioning Therapy (MERIT) trial recruited 80 consecutive patients undergoing elective angioplasty with drug-eluting stents to receive two 5-min lower limb tourniquet occlusions or an un-inflated tourniquet (controls) 1\u2009h before the procedure. The primary outcome was troponin T level at 24\u2009h. Secondary outcomes were intra-procedural chest pain and ST-segment deviation.<\/jats:p>\n                  <jats:p>Results: 6 patients in the control group and 2 in the ischemic preconditioning group had pre-procedural raised troponin T ( p\u2009=\u20090.23). This increased to 16 (40%) in the control group and 5 (12.5%) in the study group at 24\u2009h ( p\u2009=\u20090.01). Fewer patients in the study group experienced intra-procedural chest pain (1 vs. 7, p\u2009=\u20090.056). Mean ST-segment deviation time was 13\u2009\u00b1\u200935\u2009s in the study group and 58\u2009\u00b1\u2009118\u2009s in the control group ( p\u2009=\u20090.02). At a mean follow-up of 11 months, the major adverse cardiac event rate did not differ significantly between the groups.<\/jats:p>\n                  <jats:p>Conclusion: These data suggest that ischemic preconditioning reduces the absolute risk of post-procedure cardiomyocyte necrosis by 27.5%, and reduces intra-procedural chest pain and ST-segment deviation in patients undergoing percutaneous coronary interventions. We suggest its routine use in percutaneous coronary intervention, although the long-term prognostic impact in this patient group warrants further investigation.<\/jats:p>","DOI":"10.1177\/0218492312439999","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T09:37:22Z","timestamp":1367833042000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Remote ischemic preconditioning in percutaneous coronary revascularization: a double-blind randomized controlled clinical trial"],"prefix":"10.1177","volume":"20","author":[{"given":"Ali","family":"Ghaemian","sequence":"first","affiliation":[{"name":"Mazandaran Heart Institute, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Mahmoud","family":"Nouraei","sequence":"additional","affiliation":[{"name":"Mazandaran Heart Institute, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Abdollahian","sequence":"additional","affiliation":[{"name":"Mazandaran Heart Institute, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Naghshvar","sequence":"additional","affiliation":[{"name":"Mazandaran Heart Institute, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino A","family":"Giussani","sequence":"additional","affiliation":[{"name":"Department of Physiology, Neuroscience & Development, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SA Reza","family":"Nouraei","sequence":"additional","affiliation":[{"name":"Department of Physiology, Neuroscience & Development, University of Cambridge, Cambridge, UK"},{"name":"Department of ENT Surgery, Charing Cross Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-0218492312439999","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21345"},{"key":"bibr2-0218492312439999","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/CIRCULATIONAHA.105.001685","volume":"114","author":"Levitsky 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