{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:14:26Z","timestamp":1777526066675,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Levosimendan is a new calcium sensitizing drug with vasodilatory and inotropic properties, which is used for the treatment of postoperative low cardiac output syndrome and difficult weaning from cardiopulmonary bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the hemodynamic effects of levosimendan during and after coronary artery bypass grafting on cardiopulmonary bypass and mitral valve repair in patients with low left ventricular ejection fractions (&lt;30%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      40 patients were enrolled in this double-blind prospective randomized controlled trial. They received either levosimendan or a placebo preoperatively (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920) for 24\u2009h. Clinical parameters were measured before and after administration. Any adverse events during and after drug administration and postoperative complications were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients treated with levosimendan exhibited a higher cardiac index and mean arterial pressure intraoperative and in the early postoperative period, compared to the control group. Patients treated with levosimendan required less ventilatory support (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and had shorter intensive care unit (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and hospital stay (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative treatment with levosimendan in patients undergoing coronary artery bypass grafting and mitral valve repair resulted in improved hemodynamics and a stable postoperative course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492313499352","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T22:00:53Z","timestamp":1382738453000},"page":"539-545","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Preoperative levosimendan in ischemic mitral valve repair"],"prefix":"10.1177","volume":"22","author":[{"given":"Pranav","family":"Sharma","sequence":"first","affiliation":[{"name":"UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Malhotra","sequence":"additional","affiliation":[{"name":"UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Gandhi","sequence":"additional","affiliation":[{"name":"UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Garg","sequence":"additional","affiliation":[{"name":"UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Bishnoi","sequence":"additional","affiliation":[{"name":"UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemang","family":"Gandhi","sequence":"additional","affiliation":[{"name":"UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/096721099600400106"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34725-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199908000-00007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1997.0806"},{"key":"e_1_3_2_6_2","unstructured":"WMA Declaration of Helsinki\u2009-\u2009Ethical Principles for Medical Research Involving Human Subjects. Available at: http:\/\/www.wma.net\/en\/30publications\/10policies\/b3. Accessed July 3 2013."},{"key":"e_1_3_2_7_2","first-page":"125","article-title":"Preoperative levosimendan decreases mortality and the development of low cardiac output in high risk patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting with cardiopulmonary bypass","volume":"17","author":"Levin R","year":"2012","unstructured":"Levin R, Degrange M, Del Mazo C, Tanus E, Porcile R. Preoperative levosimendan decreases mortality and the development of low cardiac output in high risk patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting with cardiopulmonary bypass. Exp Clin Cardiol 2012; 17: 125\u2013130.","journal-title":"Exp Clin Cardiol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen367"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(89)90008-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)34278-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3024"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.4.2633"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.01.008"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.07.010"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.05.001"},{"key":"e_1_3_2_16_2","first-page":"338","article-title":"Hemodynamic effects of levosimendan compared with dobutamine in patients with low cardiac output after cardiac surgery","volume":"59","author":"Alvarez J","year":"2006","unstructured":"Alvarez J, Bouzada M, Fernandez AL, . Hemodynamic effects of levosimendan compared with dobutamine in patients with low cardiac output after cardiac surgery. Rev Esp Cardiol 2006; 59: 338\u2013345.","journal-title":"Rev Esp Cardiol"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael082"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318232962a"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10263"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492313499352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0218492313499352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492313499352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:28:24Z","timestamp":1777393704000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0218492313499352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,25]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1177\/0218492313499352"],"URL":"https:\/\/doi.org\/10.1177\/0218492313499352","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,25]]}}}