{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:14:29Z","timestamp":1777526069505,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the relationship between plasma high-sensitivity C-reactive protein level and the risk of recurrent coronary and cerebral ischemic events after ischemic stroke in patients with arterial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>102 patients with mild-to-moderate arterial hypertension (67 male, aged 56\u201368 years) were enrolled in the study. Serum high-sensitivity C-reactive protein was determined on study entry only. Clinical interviews were performed every 3 months during 1 year after blood sampling. Clinical events included confirmed ischemic stroke or transient ischemic attack, coronary ischemic events, sudden death, diabetes mellitus, and all cardiovascular events including chronic heart failure and hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients in the highest quartile of high-sensitivity C-reactive protein levels had a significantly higher adjusted odds ratio for clinical events compared to those in the first quartile (odds ratio\u2009=\u20097.46, 95% confidence interval: 1.55\u201319.6, p\u2009=\u20090.001). A receiver operating characteristic curve detected a plasma high-sensitivity C-reactive protein cutoff level of 5.58\u2009mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      (76.7% sensitivity, 80.3% specificity). A Cox regression model identified high-sensitivity C-reactive protein &gt;5.58\u2009mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      as an independent predictor of further cardiovascular events (hazard ratio\u2009=\u20097.14, 95% confidence interval: 1.15\u201312.6, p\u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We suggest that high-sensitivity C-reactive protein levels &gt;5.58\u2009mg\u00b7L\n                      <jats:sup>\u22121<\/jats:sup>\n                      strongly predict increased risk of cumulative cardiovascular events after ischemic stroke in hypertensive patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492313501163","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T23:39:54Z","timestamp":1383089994000},"page":"551-557","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["C-reactive protein after stroke in arterial hypertension"],"prefix":"10.1177","volume":"22","author":[{"given":"Alexander E","family":"Berezin","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Zaporozhye State Medical University, Zaporozhye, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oxana A","family":"Lisovaya","sequence":"additional","affiliation":[{"name":"Cardiology Department, District Hospital #6, Zaporozhye State Medical University, Zaporozhye, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"bibr1-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1586\/erc.11.159"},{"key":"bibr2-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.917"},{"key":"bibr3-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098151"},{"key":"bibr4-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1159\/000074791"},{"key":"bibr5-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.5.981"},{"key":"bibr6-0218492313501163","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802481200"},{"key":"bibr7-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.06.002"},{"key":"bibr8-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100012713"},{"key":"bibr9-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"bibr10-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-6"},{"key":"bibr11-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000217744.89208.4e"},{"key":"bibr12-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000089920.93927.A7"},{"key":"bibr13-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1310"},{"key":"bibr14-0218492313501163","doi-asserted-by":"publisher","DOI":"10.3109\/09638288809164103"},{"key":"bibr15-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"bibr16-0218492313501163","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-7-200110020-00014"},{"key":"bibr17-0218492313501163","unstructured":"American College of Cardiology Foundation\/American Heart Association Task Force; American Stroke Association; American Association of Neuroscience Nurses; American Association of Neurological Surgeons; American College of Radiology; American Society of Neuroradiology; Congress of Neurological Surgeons; Society of Atherosclerosis Imaging and Prevention; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology; Society of NeuroInterventional Surgery; Society for Vascular Medicine; Society for Vascular Surgery; American Academy of Neurology; Society of Cardiovascular Computed Tomography, Brott TG, Halperin JL, Abbara S, et\u00a0al. 2011 ASA\/ACCF\/AHA\/AANN\/AANS\/ACR\/ASNR\/CNS\/SAIP\/SCAI\/SIR\/SNIS\/SVM\/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary.\n                      J Neurointerv Surg\n                      2011;3:100\u201330."},{"key":"bibr18-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.161596"},{"key":"bibr19-0218492313501163","doi-asserted-by":"crossref","unstructured":"Tu WJ, Zhao SJ, Liu TG, Yang DG, Chen H. Combination of high-sensitivity C-reactive protein and homocysteine predicts the short-term outcomes of Chinese patients with acute ischemic stroke. Neurol Res 2013 May 28. [Epub ahead of print].","DOI":"10.1179\/1743132813Y.0000000228"},{"key":"bibr20-0218492313501163","first-page":"265","volume":"24","author":"Zhou P","year":"2012","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"bibr21-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.11.008"},{"key":"bibr22-0218492313501163","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.07.021"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492313501163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0218492313501163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492313501163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:28:25Z","timestamp":1777393705000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0218492313501163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1177\/0218492313501163"],"URL":"https:\/\/doi.org\/10.1177\/0218492313501163","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]}}}