{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:06:17Z","timestamp":1777550777665,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis is one of the complications following open heart surgery. Toll-like receptor 2 and toll-interacting protein polymorphism influence the immune response after open heart surgery. This study aimed to assess the genetic distribution of toll-like receptor 2 N199N and toll-interacting protein rs5743867 polymorphism in the development of postoperative sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted in 108 children &lt;1-year old who underwent open heart surgery with a Basic Aristotle score \u22656. Patients with an accompanying congenital anomaly, human immunodeficiency virus infection, or history of previous open heart surgery were excluded. The patients\u2019 nutritional status and genetic polymorphism were assessed prior to surgery. The results of genetic polymorphism were obtained through genotyping. Patients\u2019 ages on the day of surgery and cardiopulmonary bypass times were recorded. The diagnosis of sepsis was established according to Surviving Sepsis Campaign criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative sepsis was observed in 21% of patients. There were 92.6% patients with toll-like receptor 2 N199N polymorphism and 52.8% with toll-interacting protein rs5743867 polymorphism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Toll-like receptor 2 N199N polymorphism tends to increase the risk of sepsis (odds ratio\u2009=\u20091.974; 95% confidence interval: 0.23\u201316.92; p\u2009=\u20090.504), while toll-interacting protein rs5743867 polymorphism tends to decrease the risk of sepsis (odds ratio\u2009=\u20090.496; 95% confidence interval: 0.19\u20131.27; p\u2009=\u20090.139) in infants &lt;1-year old undergoing complex open heart surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492316640128","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T21:55:30Z","timestamp":1458597330000},"page":"326-331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic polymorphism in postoperative sepsis after open heart surgery in infants"],"prefix":"10.1177","volume":"24","author":[{"given":"Dicky","family":"Fakhri","sequence":"first","affiliation":[{"name":"Pediatric and Congenital Heart Surgery Unit, Department of Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samsuridjal","family":"Djauzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri Wahyu","family":"Murni","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jusuf","family":"Rachmat","sequence":"additional","affiliation":[{"name":"Thoracic and Cardiovascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alida Roswita","family":"Harahap","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri Endah","family":"Rahayuningsih","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Division, Department of Pediatrics, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muchtaruddin","family":"Mansyur","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Santoso","sequence":"additional","affiliation":[{"name":"Research and Development Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"bibr1-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.11.048"},{"key":"bibr2-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1177\/2150135111403781"},{"key":"bibr3-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200116001-00006"},{"key":"bibr4-0218492316640128","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004027"},{"key":"bibr5-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3301"},{"key":"bibr6-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1038\/nri2075"},{"key":"bibr7-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1086\/431990"},{"key":"bibr8-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1038\/35014038"},{"key":"bibr9-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181e6a068"},{"key":"bibr10-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1186\/cc9413"},{"key":"bibr11-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827e83af"},{"key":"bibr12-0218492316640128","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03658-5"},{"key":"bibr13-0218492316640128","unstructured":"World Health Organization: Department of Communicable Disease, Surveillance and Response. Prevention of hospital-acquired infections: a practical guide. 2nd Edition. Available at: www.who.int\/csr\/resources\/publications\/drugresist\/WHO_CDS_CSR_EPH_2002_12\/en. Accessed February 11, 2016."}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492316640128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0218492316640128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492316640128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:52:12Z","timestamp":1777398732000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0218492316640128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/0218492316640128"],"URL":"https:\/\/doi.org\/10.1177\/0218492316640128","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]}}}