{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:08:58Z","timestamp":1777550938689,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T00:00:00Z","timestamp":1477094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aortic valve replacement with stentless bioprostheses has been shown to produce lower aortic gradients than stented bioprostheses, thus facilitating left ventricular mass regression and preventing heart failure. We sought to determine the long-term results of stentless biological aortic valve replacement over a 17-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 1996 and 2012, 2551 patients underwent isolated aortic valve replacement with a stentless prosthesis (Medtronic Freestyle) at a single center. The mean patient age was 72\u2009\u00b1\u200910 years, 55% were male, 24.1% were in New York Heart Association class I and II, 9.6% had undergone previous surgery, 18.1% had coronary artery disease, and 23.1% had diabetes. For the long-term follow-up, patients were contacted in writing and by telephone; follow-up was 96.3% complete, resulting in 11,546 patient-years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 30 days, mortality (5.4%), renal failure (3.9%), myocardial infarction (0.7%), and stroke (1.4%) rates were acceptable. During long-term follow-up of 1\u201317 years, the bleeding rate (2.9%) was higher than the thromboembolic event rate (0.7%) despite 18.1% of patients being on oral anticoagulants. New pacemaker implantation (4.5%; 0.87 events\/100 patient-years), neurological disorders (5%; 0.52 events\/100 patient-years), valve insufficiency (0.7%; 0.16 events\/100 patient-years), paravalvular leakage (0.4%; 0.09 events\/100 patient-years) and reoperation due to valvular complications (0.7%; 0.38 events\/100 patient-years) were rare. Long-term survival was 41.8%\u2009\u00b1\u20091.6 after 10 years, 21.3%\u2009\u00b1\u20092.3 after 15 years, and 12.1%\u2009\u00b1\u20093.9 after 17 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term results after aortic valve replacement with stentless biological prostheses compare favorably with those obtained with stented bioprostheses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492316675244","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T21:59:35Z","timestamp":1476827975000},"page":"868-874","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Freestyle stentless bioprosthesis for aortic valve therapy: 17-year clinical results"],"prefix":"10.1177","volume":"24","author":[{"given":"Juergen","family":"Ennker","sequence":"first","affiliation":[{"name":"Heart Center, Helios Hospital Siegburg Germany"},{"name":"Faculty of Medicine, Witten-Herdecke University, Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Meilwes","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Justus-Liebig University Giessen, Giessen, Germany"},{"name":"Department of Cardiovascular Surgery, Justus-Liebig University Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Pons-Kuehnemann","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Justus-Liebig University Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Niemann","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Justus-Liebig University Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Grieshaber","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Justus-Liebig University Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina C","family":"Ennker","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Plastic and Reconstructive Surgery, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Boening","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Justus-Liebig University Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,22]]},"reference":[{"key":"bibr1-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00195-1"},{"key":"bibr2-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00058-X"},{"key":"bibr3-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.09.047"},{"key":"bibr4-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2008.00732.x"},{"key":"bibr5-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.03.027"},{"key":"bibr6-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.08.047"},{"key":"bibr7-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03338-0"},{"key":"bibr8-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1177\/021849230301100110"},{"key":"bibr9-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-2-40"},{"key":"bibr10-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1371697"},{"key":"bibr11-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.12.055"},{"key":"bibr12-0218492316675244","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.112208"},{"key":"bibr13-0218492316675244","first-page":"768","volume":"15","author":"Aupart 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