{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:09:43Z","timestamp":1777550983342,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coagulopathy is a major problem in surgery for cyanotic congenital heart disease. Tranexamic acid has been used both topically and systemically and plays a vital role in pediatric cardiac surgery by reducing blood loss and blood product requirement. We aimed to determine the anti-fibrinolytic effectiveness of low-dose systemic or topical tranexamic acid or a combination of both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy-five patients were divided in 3 groups of 25. Group A patients were given tranexamic acid 20\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      intravenously after sternotomy and 20\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      after heparin reversal. Group B patients were given tranexamic acid 50\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      in 20\u2009mL of saline intrapericardially before sternal closure, with the drain clamped for 20\u2009min. Group C patients were given tranexamic acid 20\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      intravenously after sternotomy and 50\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      intrapericardially before sternal closure. A number of clinical variables were recorded in the first 3 postoperative days. Ventilator time, intensive care unit stay, and outcome were also recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chest tube drainage and blood product requirements were lowest in group C. Blood urea and serum creatinine levels were higher in groups A and C ( p\u2009&lt;\u20090.05). Intensive care unit stay and ventilator time were similar in all 3 groups. No patient died and none had a seizure or other neurological event or thromboembolic complication postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of low-dose intravenous and topical tranexamic acid reduces postoperative blood loss and blood product requirement without incurring neurological, renal or thromboembolic complications. We recommend the routine use of topical and low-dose systemic tranexamic acid in cyanotic pediatric cardiac surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492316688416","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:05:46Z","timestamp":1484006746000},"page":"118-122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Topical and low-dose intravenous tranexamic acid in cyanotic cardiac surgery"],"prefix":"10.1177","volume":"25","author":[{"given":"Jigar","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrugesh","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hardik","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medical Officer, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemang","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Deodhar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himani","family":"Pandya","sequence":"additional","affiliation":[{"name":"Department of Research, UN Mehta Institute of Cardiology and Research Center, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"bibr1-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80166-4"},{"key":"bibr2-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)90451-9"},{"key":"bibr3-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)35695-8"},{"key":"bibr4-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(94)90612-2"},{"key":"bibr5-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830230306"},{"key":"bibr6-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70050-8"},{"key":"bibr7-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70374-4"},{"key":"bibr8-0218492316688416","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-4-25"},{"key":"bibr9-0218492316688416","first-page":"36","volume":"5","author":"Yasim 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