{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:10:06Z","timestamp":1777551006840,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bicuspid aortic valve patients have an increased risk of aortic dilatation. A deficit of nitric oxide synthase has been proposed as the causative factor. No correlation between flow-mediated dilation and aortic diameter has been performed in patients with bicuspid aortic valves and normal aortic diameters. Being a hereditary disease, we compared echocardiographic features and endothelial function in these patients and their first-degree relatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Comprehensive physical examinations, routine laboratory tests, transthoracic echocardiography, and measurements of endothelium-dependent and non-dependent flow-mediated vasodilatation were performed in 18 bicuspid aortic valve patients (14 type 1 and 4 type 2) and 19 of their first-degree relatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The first-degree relatives were younger (36.7\u2009\u00b1\u200918.8 vs. 50.5\u2009\u00b1\u200913.9 years, p\u2009=\u20090.019) with higher ejection fractions (64.6%\u2009\u00b1\u20091.7% vs. 58.4%\u2009\u00b1\u20099.5%, p\u2009=\u20090.015). Aortic diameters indexed to body surface area were similar in both groups, the except the tubular aorta which was larger in bicuspid aortic valve patients (19.3\u2009\u00b1\u20092.7 vs. 17.4\u2009\u00b1\u20092.2\u2009mm\u00b7m\n                      <jats:sup>\u22122<\/jats:sup>\n                      , p\u2009=\u20090.033). Flow-dependent vasodilation was similar in both groups. A significant inverse correlation was found between non-flow-dependent vasodilation and aortic root diameter in patients with bicuspid aortic valve ( R\u2009=\u2009\u22120.57, p\u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bicuspid aortic valve patients without aortopathy have larger ascending aortic diameters than their first-degree relatives. Endothelial function is similar in both groups, and there is no correlation with ascending aorta diameter. Nonetheless, an inverse correlation exists between non-endothelial-dependent dilation and aortic root diameter in bicuspid aortic valve patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492317696375","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T04:36:14Z","timestamp":1488515774000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Aortic assessment of bicuspid aortic valve patients and their first-degree relatives"],"prefix":"10.1177","volume":"25","author":[{"given":"Pablo","family":"Straneo","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Parma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Lluberas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Marichal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Soca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Cura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J","family":"Paganini","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Brusich","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Florio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Dayan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"bibr1-0218492317696375","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.795401"},{"key":"bibr2-0218492317696375","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1317"},{"key":"bibr3-0218492317696375","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.080"},{"key":"bibr4-0218492317696375","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.027"},{"key":"bibr5-0218492317696375","unstructured":"Erbel R. 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