{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:10:29Z","timestamp":1777551029654,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic examination for distant metastases is generally recommended for all lung cancer patients. However, this approach rarely detects distant metastases in typically resectable cT1-2N0 non-small-cell lung cancer. The aim of this study was to identify factors associated with distant metastases and develop indication criteria for preoperative systemic examination in patients with cT1-2N0 non-small-cell lung cancer, with a particular focus on computed tomography imaging of primary lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed non-small-cell lung cancer patients treated at our institute between 2005 and 2013. Data were extracted and compared between two groups: patients diagnosed as cT1-2N0M0 who underwent complete resection (M0 group, n\u2009=\u20091530) and those diagnosed as cT1-2N0M1b who received systemic chemotherapy (M1 group, n\u2009=\u200926).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age at diagnosis was significantly lower in the M1 group ( p\u2009=\u20090.015). Although carcinoembryonic antigen levels were significantly higher in the M1 group ( p\u2009&lt;\u20090.001), 42% had normal levels. Tumor diameters in lung and mediastinal windows on chest computed tomography were significantly larger, and the proportion (mediastinal\/lung window tumor diameter ratio) was higher in the M1 group ( p\u2009&lt;\u20090.001). All 26 patients in the M1 group had a tumor diameter &gt;15\u2009mm and mediastinal\/lung window ratio &gt;0.75.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative systemic examination is not necessary in cT1-2N0 non-small-cell lung cancer patients when tumor diameters are \u226415\u2009mm and mediastinal\/lung window ratios are \u22640.75. According to these criteria, systemic examinations would have been reduced by 40% in our cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492317709698","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T11:39:53Z","timestamp":1494502793000},"page":"281-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of indication criteria for preoperative examination in lung cancer"],"prefix":"10.1177","volume":"25","author":[{"given":"Masayuki","family":"Nakao","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgical Oncology, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyon","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology, Cancer Institute Hospital, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cancer Institute, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, The Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"bibr1-0218492317709698","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"bibr2-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040938"},{"key":"bibr3-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099314"},{"key":"bibr4-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1038\/nature05945"},{"key":"bibr5-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70364-X"},{"key":"bibr6-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2355"},{"key":"bibr9-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318206a221"},{"key":"bibr10-0218492317709698","unstructured":"Goldstraw P. Staging Manual in Thoracic Oncology, Denver, CO: IASLC, 2009, pp. 92\u2013109."},{"key":"bibr11-0218492317709698","unstructured":"International Union Against Cancer. Sobin LH, G.M., Wittekind CH, TNM Classification of Malignant Tumours, 7th ed. New York, NY: Wiley-Liss, 2009, pp. 136\u2013146."},{"key":"bibr13-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31821038ab"},{"key":"bibr14-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.02.007"},{"key":"bibr15-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182641b5c"},{"key":"bibr16-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430404"},{"key":"bibr17-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08352-6"},{"key":"bibr18-0218492317709698","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.7.914"},{"key":"bibr19-0218492317709698","first-page":"1016","volume":"39","author":"Higashi K","year":"1998","journal-title":"J Nucl Med"},{"key":"bibr20-0218492317709698","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.6862"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492317709698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0218492317709698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492317709698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:53:05Z","timestamp":1777398785000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0218492317709698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/0218492317709698"],"URL":"https:\/\/doi.org\/10.1177\/0218492317709698","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}