{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:15:07Z","timestamp":1777551307576,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The underlying pathophysiologic mechanisms of aortic stenosis are not clear. Mitochondrial dysfunction plays a role in many pathological conditions including cardiac diseases. We aimed to analyze the mitochondrial DNA haplogroups in a group of patients undergoing valve replacement surgery due to severe aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mitochondrial DNA haplogroups were assessed in 176 patients with severe aortic stenosis and 308 control subjects. Cardiovascular risk factors and demographics were similar in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients carrying haplogroup Uk had a lower risk of developing aortic stenosis, especially compared to patients carrying haplogroup H (odds ratio\u2009=\u20090.507; 95% confidence interval: 0.270\u20130.952, p\u2009=\u20090.035).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mitochondrial DNA haplogroups could be involved in the development of severe aortic stenosis. Specifically, haplogroup H could be a risk factor and Uk a protective factor for severe aortic stenosis in a population from Spain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492318813220","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T22:40:13Z","timestamp":1541716813000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Mitochondrial DNA haplogroups influence the risk of aortic stenosis"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8759-7510","authenticated-orcid":false,"given":"Maria E.","family":"Serrano-Teruel","sequence":"first","affiliation":[{"name":"Congenital & Structural Heart Disease, A Coru\u00f1a Biomedical Research Institute (INIBIC) A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Garcia-Vieites","sequence":"additional","affiliation":[{"name":"Congenital & Structural Heart Disease, A Coru\u00f1a Biomedical Research Institute (INIBIC) A Coru\u00f1a, Spain"},{"name":"Department of Cardiovascular Surgery. University Hospital Complex A Coru\u00f1a (CHUAC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Rego-Perez","sequence":"additional","affiliation":[{"name":"Genomic Group. A Coru\u00f1a Biomedical Research Institute (INIBIC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Domenech-Garcia","sequence":"additional","affiliation":[{"name":"Biobank A Coru\u00f1a. A Coru\u00f1a Biomedical Research Institute (INIBIC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Blanco-Garcia","sequence":"additional","affiliation":[{"name":"Genomic Group. A Coru\u00f1a Biomedical Research Institute (INIBIC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose J.","family":"Cuenca-Castillo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery. University Hospital Complex A Coru\u00f1a (CHUAC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Bautista-Hernandez","sequence":"additional","affiliation":[{"name":"Congenital & Structural Heart Disease, A Coru\u00f1a Biomedical Research Institute (INIBIC) A Coru\u00f1a, Spain"},{"name":"Department of Cardiovascular Surgery. University Hospital Complex A Coru\u00f1a (CHUAC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"bibr1-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00786-1"},{"key":"bibr2-0218492318813220","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3048"},{"key":"bibr3-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.961474"},{"key":"bibr4-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044128"},{"key":"bibr5-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2013.03.005"},{"key":"bibr6-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr280"},{"key":"bibr7-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1002\/art.23659"},{"key":"bibr8-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.015"},{"key":"bibr9-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109034"},{"key":"bibr10-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022567"},{"key":"bibr11-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.524835"},{"key":"bibr12-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071904"},{"key":"bibr13-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.756809"},{"key":"bibr14-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2008.10.002"},{"key":"bibr15-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.043"},{"key":"bibr16-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-009-9215-9"},{"key":"bibr17-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr280"},{"key":"bibr18-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0843-y"},{"key":"bibr19-0218492318813220","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300690110"},{"key":"bibr20-0218492318813220","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0212-8241(05)71587-5","volume":"22","author":"Banegas JR.","year":"2005","journal-title":"Hipertensi\u00f3n"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492318813220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0218492318813220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0218492318813220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:53:58Z","timestamp":1777398838000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0218492318813220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/0218492318813220"],"URL":"https:\/\/doi.org\/10.1177\/0218492318813220","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]}}}