{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:20:31Z","timestamp":1777551631674,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Levosimendan is an effective calcium sensitizer with complementary mechanisms of action: calcium sensitization and opening of adenosine triphosphate-dependent potassium channels, both on the sarcolemma of the smooth muscle cells in the vasculature and on the mitochondria of cardiomyocytes. Levosimendan has a long-acting metabolite with a half-life of approximately 80 h. There have been a few small studies on this drug regarding right ventricular function. In view of this, we investigated the effect of levosimendan on right ventricular function in patients with coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, randomized, double-blind study on 50 patients with coronary artery disease and severe left ventricular dysfunction (left ventricular ejection fraction \u226435%) undergoing elective off-pump coronary artery bypass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Levosimendan had an inotropic effect on right ventricular myocardium and a vasodilatory effect on blood vessels. It caused a decline in pulmonary vascular resistance ( p\u2009&lt;\u20090.018), right ventricular systolic pressure ( p\u2009&lt;\u20090.001), and pulmonary artery systolic pressure ( p\u2009&lt;\u20090.001), and improved right ventricular diastolic function as shown by the decrease in right ventricular Tei index ( p\u2009&lt;\u20090.001), right ventricular end-diastolic pressure, and the ratio of early diastolic tricuspid inflow to tricuspid lateral annular velocity ( p\u2009&lt;\u20090.006). However, we found no beneficial effects on intensive care unit or hospital stay ( p\u2009=\u20090.164, p\u2009=\u20090.349, respectively) nor a mortality benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Levosimendan has salutary effects on right ventricular function in patients with severe left ventricular dysfunction undergoing coronary artery bypass, in terms of improved hemodynamic parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0218492320972891","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T23:34:46Z","timestamp":1604446486000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre-bypass levosimendan in ventricular dysfunction-effect on right ventricle"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-284X","authenticated-orcid":false,"given":"Dhanesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, National Heart Institute, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Om Prakash","family":"Yadava","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, National Heart Institute, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Ahlawat","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, National Heart Institute, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, National Heart Institute, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, National Heart Institute, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, National Heart Institute, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"bibr1-0218492320972891","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2013.0258"},{"key":"bibr2-0218492320972891","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_19_18"},{"key":"bibr3-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b0314a"},{"key":"bibr4-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.06.052"},{"key":"bibr5-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519835087"},{"key":"bibr6-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-008-1077-2"},{"key":"bibr7-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12699"},{"key":"bibr8-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1177\/2045894018790905"},{"key":"bibr9-0218492320972891","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1616325"},{"key":"bibr10-0218492320972891","first-page":"e31","volume":"14","author":"Brezina 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