{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:22:20Z","timestamp":1777551740081,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study is to identify patients with thymoma who should receive post-operative radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Surveillance, Epidemiology, and End Results database was queried for stage IIB\u2013IV thymoma patients diagnosed during 1988\u20132015. We analyzed the prognostic implications of various clinical\u2013pathological factors by comparing the outcomes of those who received surgery with and without post-operative radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1120 patients were identified; 62% received post-operative radiotherapy and 38% underwent surgery alone. In a propensity-matched cohort of 812 patients, no survival difference was seen in World Health Organization A, AB, B1, B2, or B3 tumors with the addition of post-operative radiotherapy to surgery (p&gt;0.05). Post-operative radiotherapy also did not improve survival over surgery alone for tumors \u2265 or\u2009&lt;\u2009less than the 4 cm, 7 cm, 10 cm, and 13 cm cutoffs, all p&gt;0.05. Post-operative radiotherapy was an independent, positive prognostic indicator only in the subgroup with stage III disease and in those receiving chemotherapy in addition to post-operative radiotherapy, both p&lt;0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with stage III thymoma are most likely to benefit from the addition of post-operative radiotherapy to surgical treatments. Tumor size or World Health Organization histology alone should not be criteria for determining the need for post-operative radiotherapy in locally advanced thymoma. Masaoka\u2013Koga stage, which has traditionally been used to help make such decisions, appears to be the most reliable determinant of the use of post-operative radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02184923211017094","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T01:47:34Z","timestamp":1620784054000},"page":"935-942","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Invasive thymoma \u2013 Which patients benefit from post-operative radiotherapy?"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-4256","authenticated-orcid":false,"given":"Zaid","family":"Muslim","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Nuvance Health System, Connecticut & New York, USA"},{"name":"Rudy L. Ruggles Biomedical Research Institute, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirza Zain","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Nuvance Health System, Connecticut & New York, USA"},{"name":"Rudy L. Ruggles Biomedical Research Institute, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna F","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Nuvance Health System, Connecticut & New York, USA"},{"name":"Rudy L. Ruggles Biomedical Research Institute, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank C","family":"Detterbeck","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Yale University School of Medicine, New Haven, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cliff P","family":"Connery","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Nuvance Health System, Connecticut & New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Spera","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Danbury Hospital, Nuvance Health System, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz Y","family":"Bhora","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Nuvance Health System, Connecticut & New York, USA"},{"name":"Rudy L. Ruggles Biomedical Research Institute, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"bibr1-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181a4b8e0"},{"key":"bibr2-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f20c05"},{"key":"bibr3-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.016"},{"key":"bibr4-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181e8f345"},{"key":"bibr5-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.06.011"},{"key":"bibr6-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.010"},{"key":"bibr7-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000619"},{"key":"bibr8-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-291"},{"key":"bibr9-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz001"},{"key":"bibr10-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw178"},{"key":"bibr11-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.01.007"},{"key":"bibr12-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.03.004"},{"key":"bibr13-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.03.020"},{"key":"bibr14-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318207cd74"},{"key":"bibr15-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.11.022"},{"key":"bibr16-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.01.002"},{"key":"bibr17-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.07.032"},{"key":"bibr18-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000024"},{"key":"bibr19-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000303"},{"key":"bibr20-02184923211017094","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw267"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02184923211017094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02184923211017094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02184923211017094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:55:45Z","timestamp":1777398945000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02184923211017094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,11]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/02184923211017094"],"URL":"https:\/\/doi.org\/10.1177\/02184923211017094","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,11]]}}}