{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:14:29Z","timestamp":1777576469619,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T00:00:00Z","timestamp":1676160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asian Cardiovasc Thorac Ann"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperhomocysteinemia is associated with an increased risk for cardiovascular diseases. The influence of hyperhomocysteinemia on post-operative events, after coronary artery bypass surgery graft, is less studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study aimed to determine if hyperhomocysteinemia was associated with post-operative complications in patients &lt; 50 years who underwent off-pump coronary artery bypass graft for coronary artery disease. A set of major post-operative complications were considered as primary outcome measures. The independent effect of hyperhomocysteinemia and other risk factors in the incidence of post-operative complications was determined by multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean homocysteine levels among the study participants who had post-operative complications were significantly higher than those without post-operative complications (17.37\u2005mmol\/L vs. 12.84\u2005mmol\/L). On multivariate analysis, hyperhomocysteinemia, diabetes mellitus, and higher body mass index (&gt; 25) were significant predictors of adverse events during the post-operative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hyperhomocysteinemia was a significant predictor of immediate post-operative adverse events after coronary artery bypass surgery graft. Necessary precautions and management strategies have to be evolved for these high-risk subsets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02184923231156731","type":"journal-article","created":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T23:51:08Z","timestamp":1676245868000},"page":"210-214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The association of hyperhomocysteinemia with acute post-operative complications following coronary artery bypass grafting"],"prefix":"10.1177","volume":"31","author":[{"given":"Bipin Thomas","family":"Panicker","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Government Medical College Hospital Kottayam, Kottayam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-6292","authenticated-orcid":false,"given":"Sivaprasad","family":"Veerapudran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Government Medical College Hospital Kottayam, Kottayam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthi","family":"Damodaran","sequence":"additional","affiliation":[{"name":"Azeezia Medical College Hospital, Kollam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Government Medical College Hospital Kottayam, Kottayam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayakumar Thanathu","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Government Medical College Hospital Kottayam, Kottayam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,12]]},"reference":[{"key":"bibr1-02184923231156731","first-page":"343","volume":"48","author":"Enas EA","year":"1996","journal-title":"Indian Heart J"},{"key":"bibr2-02184923231156731","first-page":"749","volume":"53","author":"Sastry BK","year":"2001","journal-title":"Indian Heart J"},{"key":"bibr3-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq197"},{"key":"bibr4-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)80014-1"},{"key":"bibr5-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319894679"},{"key":"bibr6-02184923231156731","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4103\/0971-5916.93429","volume":"135","author":"Gupta SK","year":"2012","journal-title":"Indian J Med Res"},{"key":"bibr7-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00179-6"},{"key":"bibr8-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp015"},{"key":"bibr9-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74596-7"},{"key":"bibr10-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1177\/0218492309348635"},{"key":"bibr11-02184923231156731","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140706142335"},{"key":"bibr12-02184923231156731","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01474-z"},{"key":"bibr13-02184923231156731","first-page":"CD006612","volume":"8","author":"Mart\u00ed-Carvajal AJ","year":"2017","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Asian Cardiovascular and Thoracic Annals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02184923231156731","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02184923231156731","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02184923231156731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:28:22Z","timestamp":1777404502000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/02184923231156731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,12]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/02184923231156731"],"URL":"https:\/\/doi.org\/10.1177\/02184923231156731","relation":{},"ISSN":["0218-4923","1816-5370"],"issn-type":[{"value":"0218-4923","type":"print"},{"value":"1816-5370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,12]]}}}