{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:28:44Z","timestamp":1790724524668,"version":"4.1.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Indian Journal of Psychological Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Dengue is an arboviral infection endemic in tropical countries. Neurological sequelae to dengue infection are not uncommon, and psychiatric manifestations are increasingly reported. This narrative review aims to present the varied manifestations, postulated mechanisms, and the available treatment options for psychiatric morbidity associated with dengue. The evidence available from eight observational studies is summarized in this review. Depression and anxiety are noted to be prevalent during both the acute and convalescent stages of the infection. The presence of encephalopathy and other neurological conditions is not a prerequisite for developing psychiatric disorders. However, treatment options to manage such psychiatric manifestations were not specified in the observational studies. Anecdotal evidence from case reports is outlined. Special attention is paid to the role of epigenetic modifications following dengue infections and the role of histone deacetylase inhibitors in the management. DNA methylation inhibitors such as valproic acid play a significant role in reversing stress-, viral-, or drug-induced epigenetic modifications.<\/jats:p>","DOI":"10.1177\/02537176211022571","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T12:52:27Z","timestamp":1625230347000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-8168","authenticated-orcid":false,"given":"Damodharan","family":"Dinakaran","sequence":"first","affiliation":[{"name":"Dept. of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bengaluru, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanteemar S","family":"Sreeraj","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bengaluru, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesan","family":"Venkatasubramanian","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bengaluru, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00026-8"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00146-8"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002055"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60572-9"},{"key":"e_1_3_3_7_1","volume-title":"Dengue guidelines for diagnosis, treatment, prevention and control: New edition","author":"World Health Organization","year":"2009","unstructured":"World Health Organization Dengue guidelines for diagnosis, treatment, prevention and control: New edition. Geneva: World Health Organization, 2009."},{"key":"e_1_3_3_8_1","first-page":"334","article-title":"Clinical profile and predictors of Severe Dengue disease: A study from South India","volume":"9","author":"Agrawal VK","year":"2018","unstructured":"Agrawal VK, , Prusty BSK, , Reddy CS, . Clinical profile and predictors of Severe Dengue disease: A study from South India. Caspian J Intern Med, 2018; 9: 334\u2013340. DOI: 10.22088\/cjim.9.4.334.","journal-title":"Caspian J Intern Med"},{"key":"e_1_3_3_9_1","first-page":"373","article-title":"Dengue in India","volume":"136","author":"Gupta N","year":"2012","unstructured":"Gupta N, , Srivastava S, , Jain A, . Dengue in India. Indian J Med Res, 2012; 136: 373.","journal-title":"Indian J Med Res"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00449"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.91946"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-014-2010-x"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000935"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049475516679788"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.68655"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.12.018"},{"key":"e_1_3_3_17_1","first-page":"101","article-title":"A clinical study to see the psychological effects of dengue fever","volume":"5","author":"Gill KU","year":"2011","unstructured":"Gill KU, , Ahmad W, , and Irfan M. A clinical study to see the psychological effects of dengue fever. Pak J Med Health Sci, 2011; 5 101\u2013104.","journal-title":"Pak J Med Health Sci"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.44.3.b"},{"key":"e_1_3_3_19_1","first-page":"239","article-title":"Anxiety and depression in patients of dengue fever","volume":"37","author":"Khan MA","year":"2012","unstructured":"Khan MA, , Ahmad M, , Mir S, . Anxiety and depression in patients of dengue fever. Rawal Med J, 2012; 37 239\u2013242.","journal-title":"Rawal Med J"},{"key":"e_1_3_3_20_1","first-page":"62","article-title":"Depression, anxiety, stress and their effect upon the self-efficacy in dengue patients","volume":"30","author":"Mushtaq M","year":"2016","unstructured":"Mushtaq M, and Zahir M. Depression, anxiety, stress and their effect upon the self-efficacy in dengue patients. J Postgrad Med Inst, 2016; 30 62\u201365.","journal-title":"J Postgrad Med Inst"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13033-018-0202-6"},{"issue":"2","key":"e_1_3_3_22_1","first-page":"215","article-title":"Psychiatric morbidity among patients admitted with dengue fever","volume":"18","author":"Uvais NA","year":"2018","unstructured":"Uvais NA, and Moideen S. Psychiatric morbidity among patients admitted with dengue fever. Ankara Med J, 2018; 18(2): 215\u2013218.","journal-title":"Ankara Med J"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2011000700014"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17010099"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.22764"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-6748.98418"},{"key":"e_1_3_3_27_1","first-page":"1","article-title":"Late onset mania in dengue fever","volume":"2","author":"Tripathi S","year":"2014","unstructured":"Tripathi S, and Mishra N. Late onset mania in dengue fever. Immunol Infect Dis, 2014; 2 1\u20133.","journal-title":"Immunol Infect Dis"},{"issue":"1","key":"e_1_3_3_28_1","first-page":"37","article-title":"Late onset mania post dengue fever in an elderly patient: A case report","volume":"27","author":"Saifuddin TM","year":"2018","unstructured":"Saifuddin TM, , Ismail AF, , and Harun NA. Late onset mania post dengue fever in an elderly patient: A case report. Malays J Psychiatry, 2018; 27(1): 37\u201340.","journal-title":"Malays J Psychiatry"},{"key":"e_1_3_3_29_1","first-page":"100","article-title":"Post dengue mania: A case series","volume":"61","author":"Krishnan L","year":"2019","unstructured":"Krishnan L, , Subramoniam V, , Kazhungil F, . Post dengue mania: A case series. Indian J Psychiatry, 2019; 61: 100\u2013101. DOI: 10.4103\/psychiatry.IndianJPsychiatry_311_18.","journal-title":"Indian J Psychiatry"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12948"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.11.002"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2020.08.001"},{"key":"e_1_3_3_33_1","first-page":"58","article-title":"Post dengue psychosis","volume":"1","author":"Kar S","year":"2013","unstructured":"Kar S. Post dengue psychosis. Indian J Biol Psychiatry, 2013; 1 58\u201359.","journal-title":"Indian J Biol Psychiatry"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v37i3.16481"},{"key":"e_1_3_3_35_1","first-page":"119","article-title":"A case of psychotic disorder due to dengue fever","volume":"18","author":"Abdullah M","year":"2017","unstructured":"Abdullah M, and Bakar M. A case of psychotic disorder due to dengue fever. ASEAN J Psychiatry, 2017; 18 119\u2013122.","journal-title":"ASEAN J Psychiatry"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-2870.202104"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12020040"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0029-9"},{"key":"e_1_3_3_39_1","first-page":"1704","article-title":"[A psychiatric form of dengue after a visit to Djibouti]","volume":"31","author":"Rapp C","year":"2002","unstructured":"Rapp C, , Debord T, , Imbert P, . [A psychiatric form of dengue after a visit to Djibouti]. Presse Med, 2002; 31: 1704.","journal-title":"Presse Med"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-010-1460-8"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi.89.279"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.13110350"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049475519885798"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.116268"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2014.01.007"},{"key":"e_1_3_3_46_1","first-page":"204","article-title":"Retrospective study on dengue fatal cases","volume":"16","author":"Miagostovich MP","year":"1997","unstructured":"Miagostovich MP, , Ramos R, , Nicol A, . Retrospective study on dengue fatal cases. Clin Neuropathol, 1997; 16 204\u2013208.","journal-title":"Clin Neuropathol"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.031"},{"key":"e_1_3_3_48_1","first-page":"6803098","article-title":"Dengue fever: Causes, complications, and vaccine strategies","author":"Khetarpal N","year":"2016","unstructured":"Khetarpal N, and Khanna I. Dengue fever: Causes, complications, and vaccine strategies. J Immunol Res, 2016; 2016: 6803098. DOI: 10.1155\/2016\/6803098.","journal-title":"J Immunol Res"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666181105130000"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.03.010"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.11.014"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8797206"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01304-10"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21340"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.10.004"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3181"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-019-04406-7"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019229"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0384-y"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0079-12.2012"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.09.020"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101287200"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.00104.x"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.98"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.01.003"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1094"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005512"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4616"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.11.044"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.09.043"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08171"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16873"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC02130D"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00203.x"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2014.922537"}],"container-title":["Indian Journal of Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02537176211022571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02537176211022571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02537176211022571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:43:02Z","timestamp":1777653782000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02537176211022571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,2]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/02537176211022571"],"URL":"https:\/\/doi.org\/10.1177\/02537176211022571","relation":{},"ISSN":["0253-7176","0975-1564"],"issn-type":[{"value":"0253-7176","type":"print"},{"value":"0975-1564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,2]]}}}