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This case series explores clozapine for treatment-resistant PTSD (TR-PTSD) without psychosis. Seven soldiers showed improved function and reduced aggression at doses of 125\u2013300 mg, suggesting that clozapine warrants further investigation.<\/jats:p>","DOI":"10.1177\/02537176261469995","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T12:10:49Z","timestamp":1785067849000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clozapine for Post-traumatic Stress Disorder: Redefining Treatment Resistance in Soldiers without Psychosis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1506-9088","authenticated-orcid":false,"given":"Roshan","family":"Monaragala","sequence":"first","affiliation":[{"name":"Army Preventive Medicine and Mental Health Services, Army Headquarters, Battaramulla, Western Province, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-8228","authenticated-orcid":false,"given":"Miyuru","family":"Chandradasa","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry, University of Kelaniya, Ragama, Western Province, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-2329","authenticated-orcid":false,"given":"K.A.L.A.","family":"Kuruppuarachchi","sequence":"additional","affiliation":[{"name":"Dept. of Psychiatry, University of Kelaniya, Ragama, Western Province, Sri Lanka."},{"name":"Dept. of Psychiatry, General Sir John Kotelawala Defence University, Ratmalana, Western Province, Sri Lanka."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.01.015"},{"key":"e_1_3_3_3_2","article-title":"Toward a definition of treatment-resistant posttraumatic stress disorder: A systematic review","author":"Al-Shamali HF","year":"2025","unstructured":"Al-Shamali HF, , Meshkat S, , Janssen-Aguilar R, . Toward a definition of treatment-resistant posttraumatic stress disorder: A systematic review. J Mil Veteran Fam Health. Epub ahead of print 1 February 2025. DOI: 10.3138\/JMVFH-2025-0015.","journal-title":"J Mil Veteran Fam Health"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40501-017-0130-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2362796"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/20451253231158152"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3182aa365f"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.23192"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.5772\/23234"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/104454604773840490"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.96323"},{"key":"e_1_3_3_12_2","article-title":"Clozapine prescribing barriers in the management of treatment-resistant schizophrenia: A systematic review","author":"Baig AI","year":"2021","unstructured":"Baig AI, , Bazargan-Hejazi S, , Ebrahim G, . Clozapine prescribing barriers in the management of treatment-resistant schizophrenia: A systematic review. Medicine (United States). Epub ahead of print 12 November 2021. 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