{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:21Z","timestamp":1790927661593,"version":"4.1.0"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Indian Journal of Psychological Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Purpose of the Review:<\/jats:title>\n                    <jats:p>Sex-based differences in antidepressant outcomes may influence treatment decisions in major depressive disorder (MDD). This systematic review and meta-analysis evaluated sex-based differences in the efficacy and tolerability of selective serotonin reuptake inhibitors (SSRIs) in adults with MDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Collection and Analysis of Data:<\/jats:title>\n                    <jats:p>PubMed, Cochrane Library, and Scopus were searched electronically, supplemented by citation searching. Two reviewers independently screened records and assessed full-text articles for eligibility. Of 3,523 records identified, 100 duplicates were removed, and 237 full-text articles were assessed, resulting in 10 included studies published between 2005 and 2025. Eligible studies included at least one SSRI arm with extractable sex-stratified outcome data specific to SSRIs. Risk of bias was assessed using RoB 2, the Newcastle\u2013Ottawa Scale, and design-appropriate appraisal tools. Certainty of evidence was evaluated using GRADE. Pooled estimates were generated using random-effects meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ten studies (2005\u20132025) were included. Remission (six studies, 3,865 participants) showed OR: 1.18 (95% CI: 0.96\u20131.44;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      \u00b2 = 0%); response (two studies, 3,006 participants) OR: 1.39 (95% CI: 0.87\u20132.22;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      \u00b2 = 51.8%); and continuous symptom improvement (three studies, 3,050 participants) standardized mean difference 0.40 (95% CI: 0.04\u20130.75;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      \u00b2 = 74.9%), each favoring female. Certainty ranged from moderate (remission) to low (response, continuous improvement).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SSRI efficacy outcomes showed a consistent female-favoring direction, clearest for continuous symptom improvement, but estimates were limited by heterogeneity, imprecision, and incomplete sex-stratified reporting. The evidence does not support sex-based prescribing; adequately powered, prospectively sex-stratified studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02537176261489722","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:25:41Z","timestamp":1790616341000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-based Differences in the Efficacy and Tolerability of Selective Serotonin Reuptake Inhibitors in Adults with Major Depressive Disorder: A Systematic Review and Meta-analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2010-6664","authenticated-orcid":false,"given":"Amrita Kumari","family":"Pandey","sequence":"first","affiliation":[{"name":"Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9935-0382","authenticated-orcid":false,"given":"Abhinav","family":"Tiwary","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-6943","authenticated-orcid":false,"given":"Farhan Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-161X","authenticated-orcid":false,"given":"Mohammed","family":"Reyazudin","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-1642","authenticated-orcid":false,"given":"Irfan Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 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