{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:25:31Z","timestamp":1777915531887,"version":"3.51.4"},"reference-count":72,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>The present mismatch between what our brain needs, and the modern diet neglects our marine heritage. Last century, the priority in nutrition and food production was to achieve a high protein diet and somatic growth and function. The dietary content of omega-3 (N-3) required by the brain was neglected although evidence for the essentiality of certain fatty acids was published in 1929 and specifically re-affirmed for omega 3 in the brain in the 1970s. Cognitive decline with age and neurodegenerative disorder with dementia are now rising. This review describes signs of N-3 deficit in Alzheimer and Parkinson Disease, where maximum change involves the primary sites: olfactory cortex and the hippocampus. The olfactory agnosia observed in schizophrenia supports an N-3 deficit as does a reduction of key ologodendrocyte- and myelin-related genes in this disorder and affective disorder, where a rise in dementia accords with a deficit of N-3 also in this disorder. N-3 normalizes cerebral excitability at all levels. That the two disorders are localized at the extremes of excitability, is supported by their opposing treatments: convulsant neuroleptics and anti-epileptic antidepressants. An adequate N-3 diet will probably prevent most psychotic episodes and prove that neurodegenerative disorder with dementia is also to a large extent not only preventable but avoidable.<\/jats:p>","DOI":"10.1177\/026010600601800201","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T19:28:16Z","timestamp":1326223696000},"page":"89-101","source":"Crossref","is-referenced-by-count":3,"title":["Are Neurodegenerative Disorder and Psychotic Manifestations Avoidable Brain Dysfunctions with Adequate Dietary Omega-3?"],"prefix":"10.1177","volume":"18","author":[{"given":"Letten F.","family":"Saugstad","sequence":"first","affiliation":[{"name":"Behrens' gt 5, 0257 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,1,1]]},"reference":[{"key":"bibr1-026010600601800201","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-02-00516.1997"},{"key":"bibr2-026010600601800201","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.07.007"},{"key":"bibr3-026010600601800201","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/15.4.585"},{"key":"bibr4-026010600601800201","first-page":"862","volume":"17","author":"Bjerve K.S.","year":"1987","journal-title":"Advances in Prostaglandin, Trombantine and Leukotirene Research"},{"key":"bibr5-026010600601800201","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01451.x"},{"key":"bibr6-026010600601800201","volume-title":"Diseases of the Nervous System","author":"Brain Lord","year":"1962"},{"key":"bibr7-026010600601800201","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19980004"},{"key":"bibr8-026010600601800201","first-page":"389","volume":"34","author":"Budowski P.","year":"1980","journal-title":"Ann. 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