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Trials of a treatment to lower homocysteine in moderately advanced disease have failed to show benefits (except in those not treated with anti-platelet drug), but there is mounting evidence for a role in treatment of very early disease and as a preventive strategy. Recent evidence has shown that lowering of high blood homocysteine significantly slows cognitive decline and the brain shrinkage associated with Alzheimer\u2019s disease. This is a test that should be done more frequently by National Health Service (NHS) general practitioners and private practitioners.<\/jats:p>","DOI":"10.1177\/0260106016686094","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T04:19:38Z","timestamp":1484021978000},"page":"13-15","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Testing for homocysteine in clinical practice"],"prefix":"10.1177","volume":"23","author":[{"given":"John","family":"Nichols","sequence":"first","affiliation":[{"name":"South West Thames Faculty, Royal College of General Practitioners, London, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"bibr1-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"},{"key":"bibr2-0260106016686094","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.076349"},{"key":"bibr3-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.11.1449"},{"key":"bibr4-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2016.03.010"},{"key":"bibr5-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301816110"},{"key":"bibr6-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60109-3"},{"key":"bibr8-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70091-1"},{"key":"bibr9-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2274"},{"key":"bibr10-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"bibr11-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv022"},{"key":"bibr12-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1038\/nm0496-386"},{"issue":"1","key":"bibr13-0260106016686094","first-page":"1","volume":"61","author":"McCully KS","year":"1970","journal-title":"American Journal of Pathology"},{"key":"bibr14-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707243370403"},{"key":"bibr15-0260106016686094","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150777"},{"key":"bibr16-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1177\/1747493015616512"},{"key":"bibr17-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021634"},{"key":"bibr18-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071715-050947"},{"issue":"9","key":"bibr19-0260106016686094","first-page":"e12244","volume":"5","author":"Smith AD","year":"2010","journal-title":"Public Library of Science One"},{"key":"bibr20-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2016.07.002"},{"key":"bibr21-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7374.1202"},{"key":"bibr22-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39000.486701.68"},{"key":"bibr23-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60854-X"},{"key":"bibr24-0260106016686094","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.570846"}],"container-title":["Nutrition and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0260106016686094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0260106016686094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0260106016686094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:24:07Z","timestamp":1777656247000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0260106016686094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,10]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/0260106016686094"],"URL":"https:\/\/doi.org\/10.1177\/0260106016686094","relation":{},"ISSN":["0260-1060","2047-945X"],"issn-type":[{"value":"0260-1060","type":"print"},{"value":"2047-945X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,10]]}}}