{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:26:50Z","timestamp":1777915610106,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin C levels are decreased in arthritis patients and reduced levels following surgery may impair adequate healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study measured changes in vitamin C and inflammatory markers in patients undergoing total knee arthroplasty (TKA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Venous blood samples were collected from 10 patients during the preoperative to postoperative period. Vitamin C, interleukin-1 \u03b2, interleukin-6 (IL-6), and C-reactive protein (CRP) levels were measured using various assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No significant changes in vitamin C levels were measured. However, all participants had suboptimal preoperative vitamin C levels and 90% had suboptimal levels postoperatively. IL-6 and CRP levels significantly increased during the immediate postoerative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was a rise in inflammation following TKA while vitamin C levels did not significantly change during this short study period. Of note, every patient had suboptimal vitamin C levels prior to surgery and 90% continued with suboptimal levels two days postoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0260106020910632","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T01:58:00Z","timestamp":1585619880000},"page":"87-91","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin C and inflammatory cytokine levels in elective total knee arthroplasty"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-5704","authenticated-orcid":false,"given":"Shalin","family":"Shah","sequence":"first","affiliation":[{"name":"Virginia Commonwealth University School of Medicine, McGlothlin Medical Education Center (MMEC), USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6292-2738","authenticated-orcid":false,"given":"Christopher","family":"Brown","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University School of Medicine, McGlothlin Medical Education Center (MMEC), USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Owen","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Laboratory, Virginia Commonwealth University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-2025","authenticated-orcid":false,"given":"Bernard","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Kates","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Virginia Commonwealth University, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"bibr1-0260106020910632","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2709"},{"key":"bibr2-0260106020910632","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.11.006"},{"key":"bibr3-0260106020910632","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-5030-3"},{"key":"bibr4-0260106020910632","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2015.12.039"},{"key":"bibr5-0260106020910632","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2647-x"},{"key":"bibr6-0260106020910632","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200503000-00018"},{"key":"bibr7-0260106020910632","doi-asserted-by":"crossref","unstructured":"Fowler AA III, Syed AA, Knowlson S, et al. (2014) Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. Journal of Translational Medicine 12(1): 32. 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