{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:27:09Z","timestamp":1777915629164,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim:<\/jats:title>\n                    <jats:p>High plasma cholesterol levels, mainly low-density lipoprotein-cholesterol (LDL) is a widely recognized major risk factor for coronary heart disease (CHD). According to epidemiologic studies\u2019 findings, people from the Mediterranean countries have lower CHD rates than other countries; in these countries the usual diet is high in olive oil. The present study compares the effects of a cholesterol-enriched diet with or without adding olive oil on serum lipoproteins, lipid peroxidation, and atherosclerosis development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty Dutch male rabbits were categorized into four groups (one group as control, and others as experimental). They received one of control (CON), olive oil-rich (OIL), cholesterol-rich (CHOL), and cholesterol + olive oil (COIL) diet for 12 weeks. Fasting blood samples from the heart were collected at the beginning and the end of the experimental period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Means of serum lipids were not significantly different at the beginning of the experimental period. After the intervention, significant differences were shown in total cholesterol (TC) (CON: 27.75 \u00b1 4.83, OIL: 19.75 \u00b1 2.62, CHOL: 1757.20 \u00b1 149.62, COIL: 2906.40 \u00b1 421.01; P &lt; 0.001), high-density lipoprotein-cholesterol (HDL-C) (CON: 16 \u00b1 1.47, OIL: 10.25 \u00b1 1.70, CHOL: 22.2 \u00b1 3.83, COIL: 28.60 \u00b1 6.27; P = 0.04), triglyceride (CON: 65 \u00b1 12.21, OIL: 71.75 \u00b1 6.23, CHOL: 244.2 \u00b1 44.45, COIL: 775.6 \u00b1 105.07; P &lt; 0.001), and MDA between groups (CON: 0.57 \u00b1 0.10, OIL: 0.63 \u00b1 0.15, CHOL: 5.62 \u00b1 0.18, COIL: 2.06 \u00b1 0.64; P &lt; 0.001). The comparison of CHOL and the COIL groups showed a higher mean of malondialdehyde (MDA) in group CHOL (4.47 \u00b1 0.28 vs 1.1 \u00b1 0.6; P &lt; 0.001). Aortic lesion was not observed in CON and OIL groups. Aortic lesion degree was significantly lower in the COIL group compared to the CHOL (2.4 \u00b1 0.6 vs 3.66 \u00b1 0.33; P = 0.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings showed the preventive effect of olive oil on atherosclerosis development. However, it is independent of the plasma lipoprotein effect, and olive oil probably acts on arteries directly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060211022260","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T04:11:31Z","timestamp":1623989491000},"page":"417-424","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The effects of olive oil and cholesterol enriched diets on aortic fatty streak development and lipid peroxidation in rabbits"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-2576","authenticated-orcid":false,"given":"Zamzam","family":"Paknahad","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Parisa","family":"Moosavian","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvin","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"bibr1-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00038-4"},{"key":"bibr2-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-8396-8"},{"key":"bibr3-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1097\/XCE.0000000000000175"},{"key":"bibr4-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.01.001"},{"key":"bibr5-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.06.916"},{"key":"bibr6-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.09.011"},{"key":"bibr7-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-000-0493-2"},{"key":"bibr8-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.10.029"},{"key":"bibr9-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708073370607"},{"key":"bibr10-02601060211022260","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112833"},{"key":"bibr11-02601060211022260","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S196016"},{"key":"bibr12-02601060211022260","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200303"},{"key":"bibr13-02601060211022260","unstructured":"Farahat A, Sawiress F, Aghwider A. 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