{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:27:44Z","timestamp":1777915664240,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Banco da Amaz\u00f4nia","award":["2018\/214"],"award-info":[{"award-number":["2018\/214"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Studies suggest that vitamin A deficiency (VAD) can cause night blindness or xerophthalmia, hepatic and metabolic changes in the blood.\n                    <jats:bold>Aim:<\/jats:bold>\n                    Therefore, this work aimed to stablish a model of hypovitaminosis A in rats and to evaluate the effects of vitamin A deficiency on metabolic and oxidative parameters in the liver of rats.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Male (n\u2009=\u200919), Wistar, rats (21-day-old) weighing 50g, divided into two experimental groups: Control Group (C), received AIN 93G diet and Vitamin A Deficiency Group (VAD), received AIN 93G vitamin A-free diet for 45 days. In this work, the parameters analyzed were: body mass, food and water intake, biochemical aspects in the blood, lipids and glycogen content, lipid peroxidation, carbonyl proteins and catalase activity in the liver.\n                    <jats:bold>Results:<\/jats:bold>\n                    In the VAD group, final body mass (9%), liver mass (28%), glycemia (14%), Total -cholesterol (17%), HDL -cholesterol (31%) and VLDL -cholesterol (30%) showed reduced (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The liver lipid (64%) and glyceride-fatty acid (74%) contents were higher in the VAD group. The carbonyl proteins in liver were increased by 171% (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    In summary, these results suggest that the absence of vitamin A from the diet was effective in inducing characteristics of hypovitaminosis A in rats. This way, can be used for studies related to glucose and lipid metabolism.\n                  <\/jats:p>","DOI":"10.1177\/02601060221103005","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T02:18:58Z","timestamp":1653272338000},"page":"207-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of dietary vitamin A deficiency on body physiology and liver metabolism of Wistar rats"],"prefix":"10.1177","volume":"32","author":[{"given":"Elaine Cristina de Lara","family":"Spada","sequence":"first","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Nunes da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fhelipe Jolner Souza de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela de Souza Vial","family":"Dahmer","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar Willibaldo Allebrandt","family":"Neto","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson de Oliveira","family":"Souza","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara Peron","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-8530","authenticated-orcid":false,"given":"Suelem Aparecida de","family":"Fran\u00e7a Lemes","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_3_3_3_1","unstructured":"Almeida BB (2014) Efeitos metab\u00f3licos da combina\u00e7\u00e3o de triglicer\u00eddeos de cadeia m\u00e9dia e \u00f3leo de peixe na esteatose hep\u00e1tica e estresse oxidativo induzidos pela dieta hiperlip\u00eddica termolizada em ratos. 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