{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:27:55Z","timestamp":1777915675650,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Excessive consumption of phosphorus (P) impairs renal tubule function; however, the effects of different dietary phosphate salts on chronic kidney disease (CKD) are unclear.\n                    <jats:bold>Aim:<\/jats:bold>\n                    To examine the effects of potassium dihydrogen phosphate (KH\n                    <jats:sub>2<\/jats:sub>\n                    PO\n                    <jats:sub>4<\/jats:sub>\n                    ) and potassium tripolyphosphate (K\n                    <jats:sub>5<\/jats:sub>\n                    P\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>10<\/jats:sub>\n                    ) and P concentration on renal function in a rat model of early CKD.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Male sham-operated Sprague-Dawley rats were fed a diet containing KH\n                    <jats:sub>2<\/jats:sub>\n                    PO\n                    <jats:sub>4<\/jats:sub>\n                    with a normal P level. Kidney injury was induced by unilateral nephrectomy (UNx), and the rats were divided into four groups fed dietary KH\n                    <jats:sub>2<\/jats:sub>\n                    PO\n                    <jats:sub>4<\/jats:sub>\n                    or K\n                    <jats:sub>5<\/jats:sub>\n                    P\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>10<\/jats:sub>\n                    with a normal (UNx-NKH, UNx-NKP) or high (UNx-HKH, UNx-HKP) P concentration, respectively, for 21 days.\n                    <jats:bold>Results:<\/jats:bold>\n                    UNx-NKH rats showed significantly lower creatinine clearance (CCr) and higher albumin (ALB) compared with those of sham rats, confirming UNx-induced kidney injury. The urinary levels of liver-type fatty acid-binding protein (L-FABP) and ALB were significantly higher in UNx-HKP rats than in UNx-HKH rats. However, other markers of renal tubule function, such as CCr, serum creatinine (CRE), calcium (Ca), and hormones, only differed among groups according to the P concentration and not the dietary phosphate salt form. Histological examination showed higher incidence and severity of tubulointerstitial lesions, tubule regeneration, tubule dilation, and calcification in the high-phosphorus than in the normal-phosphorus UNx groups. These changes were more severe in the UNx-HKP group compared with the UNx-HKH group.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    This study highlights the importance of controlling dietary P intake in terms of both concentration and source to prevent the progression of CKD.\n                  <\/jats:p>","DOI":"10.1177\/02601060221122223","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T02:54:20Z","timestamp":1661828060000},"page":"269-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of dietary phosphorus concentration and phosphate salt form on renal tubule function in unilateral nephrectomized rats"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-420X","authenticated-orcid":false,"given":"Kikue","family":"Mori","sequence":"first","affiliation":[{"name":"Tokyo University of Agriculture"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinuko","family":"Uno","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00072.2005"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09750913"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.54.2.382"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.09.002"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312438736"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/13.3.204"},{"key":"e_1_3_3_8_1","first-page":"955","article-title":"A modification of the colorimetric phosphorus determination for use with the photoelectric colorimeter","volume":"27","author":"Gomori G","year":"1942","unstructured":"Gomori G (1942) A modification of the colorimetric phosphorus determination for use with the photoelectric colorimeter. Journal of Laboratory and Clinical Medicine 27: 955\u2013960.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.85"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1992-9"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070602"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010043"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.928"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.43.627"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(97)00051-1"},{"issue":"2","key":"e_1_3_3_16_1","first-page":"218","article-title":"The effect of potassium dihydrogenphosphate and potassium tripolyphosphate as dietary phosphate salts on kidney function in unilateral nephrectomized rat","volume":"30","author":"Mori K","year":"2021","unstructured":"Mori K, Katsumata S, Matsuzaki H (2021) The effect of potassium dihydrogenphosphate and potassium tripolyphosphate as dietary phosphate salts on kidney function in unilateral nephrectomized rat. Journal of Japan Health Medicine Association 30(2): 218\u2013222.","journal-title":"Journal of Japan Health Medicine Association"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080644"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.106"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90589-8"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.10.1423"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32065-2"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080511"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139X.2003.16037.x"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015010006"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw203"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.03.017"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167334"}],"container-title":["Nutrition and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060221122223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02601060221122223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060221122223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:26:48Z","timestamp":1777656408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02601060221122223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/02601060221122223"],"URL":"https:\/\/doi.org\/10.1177\/02601060221122223","relation":{},"ISSN":["0260-1060","2047-945X"],"issn-type":[{"value":"0260-1060","type":"print"},{"value":"2047-945X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]}}}