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Group 1 is intact animals. The food of Group 2 (control) included traditional bread. Animals of experimental groups were fed as follows: bread, in which 75% of water were replaced with clarified tomato juice (Group 3); bread with the addition of 20% of flaxseed, soaked beforehand in clarified tomato juice (Group 4); bread similar to Group 4, but juice with dissolved flaxseed hydrocolloids was used during dough kneading (Group 5); bread similar to Group 4, but instead of juice, drinking water was used (Group 6). We studied blood biochemistry. After 6 months, we took liver samples and identified the ratio of muscle, fat, bone, and connective tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We established that the introduction of clarified tomato juice into the bread recipe yielded a decrease in cholesterol and creatinine levels (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.029 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.031, respectively), while the addition of flaxseed soaked in water can promote the activation of protective effects against nonalcoholic fatty liver disease via reducing the levels of bilirubin (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.040) and transaminases (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.013) in the blood of experimental animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The introduction of a combination of flaxseed and clarified tomato juice into the bread recipe in conjunction with its daily consumption contributed to the manifestation of protective effects for the liver of rabbits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060241298740","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T02:56:13Z","timestamp":1733799373000},"page":"1449-1463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination of flaxseed and clarified tomato juice in bread: Delayed effect on metabolic disorders during long-term unbalanced diet in an in vivo experiment"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8662-4559","authenticated-orcid":false,"given":"Irina M","family":"Zharkova","sequence":"first","affiliation":[{"name":"Department of Baking, Confectionery, Pasta and Grain Processing Technologies, Voronezh State University of Engineering Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey V","family":"Grebenshchikov","sequence":"additional","affiliation":[{"name":"Department of Baking, Confectionery, Pasta and Grain Processing Technologies, Voronezh State University of Engineering Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy P","family":"Efremov","sequence":"additional","affiliation":[{"name":"Agrolyon LLC, Barnaul and Voronezh, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey A","family":"Maksimov","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofya O","family":"Eliashevich","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia V","family":"Orekhova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine"},{"name":"Moscow State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-3950","authenticated-orcid":false,"given":"Anton R","family":"Kiselev","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"57117","article-title":"An experimental model of diet-induced metabolic syndrome in rabbit: Methodological considerations, development, and assessment","volume":"134","author":"Arias-Mutis \u00d3J","year":"2018","unstructured":"Arias-Mutis \u00d3J, Genov\u00e9s P, Calvo CJ, et al. 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