{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:29:22Z","timestamp":1777915762756,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Chlormequat (chlorocholine) is one of the most widely used plant growth regulators. It enhances the strength of cereal crops such as wheat and barley. The U.S. Environmental Protection Agency approved the use of chlormequat; however, in recent times, there has been growing concern about its health impacts, including endocrine and reproductive toxicity. Recent studies have highlighted the growing presence of chlormequat in food and biological samples, raising questions about long-term human exposure.\n                    <jats:bold>Aim:<\/jats:bold>\n                    This article highlights the critical need to review the safety issues associated with chlormequat use in food production by assessing its potential health risks and addressing existing regulatory inadequacies. By identifying gaps in current regulations and emphasizing the importance of consumer education, the article advocates for stronger food safety practices and more sustainable farming methods to reduce exposure to chlormequat. Implementing these solutions will not only mitigate potential health risks but also promote public health and improve overall food safety standards.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Not applicable.\n                    <jats:bold>Results:<\/jats:bold>\n                    Observations have shown a steady and sharp rise in the level of chlormequat detection in both food and human biological samples over these years. Animal studies have confirmed significant disturbance in reproductive and endocrine functions, although studies in humans are scant. Current regulations do not include long-term human safety, though these regulations do set limits on residues. Furthermore, improper agricultural application increases the risks of overexposure.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The result shows the implication of heightened regulatory measures, consumer awareness, and further research into the long-term effects of chlormequat on human health. Some concerns with chemical growth regulators like chlormequat could be minimized by promoting sustainable farming and precision agriculture methods.\n                  <\/jats:p>","DOI":"10.1177\/02601060251328772","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T06:37:07Z","timestamp":1742884627000},"page":"837-839","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chlormequat in our food: A potential hidden threat to health, highlighting the need for improved food safety practices"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2860-1370","authenticated-orcid":false,"family":"Abdullah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Abdullah","family":"Rizwan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Gul Rao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dow University of Medical and Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anum","family":"Akbar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_3_2_2_1","unstructured":"Chlormequat Chloride | C5H13Cl2N | CID 13836 \u2013 PubChem (n.d.). https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Chlormequat-chloride."},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.43.1.243"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2015.08.001"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2005.00629.x"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-024-00643-4"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152534"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-022-00439-4"}],"container-title":["Nutrition and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060251328772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02601060251328772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060251328772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:29:00Z","timestamp":1777656540000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02601060251328772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/02601060251328772"],"URL":"https:\/\/doi.org\/10.1177\/02601060251328772","relation":{},"ISSN":["0260-1060","2047-945X"],"issn-type":[{"value":"0260-1060","type":"print"},{"value":"2047-945X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}