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According to the International Diabetes Federation, in 2021, almost 6.7 million adults aged 20\u201379 died due to complications from diabetes. In light of this concerning statistic, novel alternatives, including bioactive compounds such as flavonoids, are undergoing clinical and scientific evaluation to hinder the advancement of metabolic disorders or maybe avert their onset.\n                    <jats:bold>Aim:<\/jats:bold>\n                    We postulate that kaempferitrin may act on glycemic homeostasis in mice challenged with high-fat, high-sucrose diet (HFHS) for 24\u2005h.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Kaempferitrin at a 100\u2005mg\/kg dose was administered to two-month-old male C57BL\/6 mice challenged with a HFHS diet for 3, 6, or 24\u2005h. Glucose intolerance was assessed by an oral glucose tolerance test (oGTT). In the liver, AMP-activated protein kinase (AMPK) was measured via western blotting, and gene expression of the phosphoenolpyruvate carboxykinase (PEPCK) enzyme was assessed by quantitative PCR (qPCR).\n                    <jats:bold>Results:<\/jats:bold>\n                    At 6\u2005h, kaempferitrin reduced the PEPCK gene expression compared to the group receiving only the HFHS diet. For the 24\u2005h challenge with the HFHS diet, kaempferitrin did not prevent glucose intolerance (oGTT). However, kaempferitrin reduced the pAMPK\/AMPK ratio and the PEPCK gene expression compared to the HFHS group.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Kaempferitrin, when administered alongside a hypercaloric and hyperlipidic diet, even for short periods, did not prevent glucose intolerance. Nevertheless, it did lead to significant modulations in AMPK phosphorylation and PEPCK gene expression.\n                  <\/jats:p>","DOI":"10.1177\/02601060251340447","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:33:05Z","timestamp":1747726385000},"page":"925-935","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Kaempferitrin modulates AMPK phosphorylation and PEPCK expression in the liver after a short-term high-fat, high-sucrose diet intervention in mice"],"prefix":"10.1177","volume":"32","author":[{"given":"Ingrid Candido","family":"Garofolo","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma Freire","family":"Santos","sequence":"additional","affiliation":[{"name":"Curso de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Ferreira","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane de Mello","family":"Veneza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica - Ci\u00eancia e Tecnologia da Sustentabilidade Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Andr\u00e9 Moura","family":"Veiga","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica - Ci\u00eancia e Tecnologia da Sustentabilidade Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"},{"name":"Departamento de Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Lucia Flor","family":"Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel Cardoso","family":"Alonso-Vale","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-4010","authenticated-orcid":false,"given":"Luciana Chagas","family":"Caperuto","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"},{"name":"Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de S\u00e3o Paulo, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas - ICAQF, Diadema, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12071406"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4520-z"},{"key":"e_1_3_3_4_1","article-title":"Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the liver tissue of STZ- induced diabetes in mice","author":"Aodah AH","year":"2024","unstructured":"Aodah AH, Alkholifi FK, Devi S, et al. 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