{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:46:56Z","timestamp":1791838016842,"version":"4.3.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["(No. 82060597"],"award-info":[{"award-number":["(No. 82060597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Nonalcoholic fatty liver disease (NAFLD) is characterized by an abnormal accumulation of lipids in the liver tissue.\n                    <jats:bold>Aim:<\/jats:bold>\n                    This study aims to evaluate the potential therapeutic effect of oral\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharide (LBP) capsules in patients with NAFLD.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A pre\u2013post-intervention clinical trial involving 13 participants, aged 28\u201350 years, was conducted at a community health center. Participants underwent abdominal ultrasound and laboratory tests, including alanine aminotransferase level measurements. During the 12-week intervention period, participants received a daily oral LBP supplement capsule (300 mg). We collected blood and stool samples at baseline and postintervention, which were for 16S rRNA gene sequencing and metabolomics analysis.\n                    <jats:bold>Results:<\/jats:bold>\n                    Postintervention, significant reductions (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) were observed in gamma-glutamyltransferase (GGT), ALB, TP, and D-BIL levels. There were 125 upregulated and 65 downregulated metabolites. LBP supplementation increased Gemmiger abundance. Microbiota diversity, analyzed through 16S rRNA sequencing, showed altered phylum distribution in fecal samples, with PICRUSt2 indicating effects on linoleic acid metabolism. Changes in negative correlations between specific lipid metabolites, such as Her2Cer(d14:0_22:6), and enzyme activities like GGT, were also noted.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    polysaccharide intervention may enhance GGT, ALB, TP, and D-BIL levels, demonstrating beneficial effects on critical biochemical parameters in NAFLD patients. Correlation analysis showed LBP alters the relationship between specific lipid metabolites and enzyme activity, notably between GGT and Her2Cer(d14:0_22:6), laying groundwork for further research on LBP's impact on NAFLD.\n                    <jats:bold>Trial registration:<\/jats:bold>\n                    Chinese Clinical Trial Registry, ChiCTR2000034740, and Institutional Ethics Committee of Ningxia Medical University, 2019-329.\n                  <\/jats:p>","DOI":"10.1177\/02601060251357979","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:54:01Z","timestamp":1754034841000},"page":"1045-1054","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Benefit of\n                    <i>Lycium barbarum<\/i>\n                    polysaccharide supplementation in patients with nonalcoholic fatty liver disease: A pre\u2013post study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-7133","authenticated-orcid":false,"given":"Yanna","family":"Fan","sequence":"first","affiliation":[{"name":"Ningxia Medical University"},{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pu","sequence":"additional","affiliation":[{"name":"Ningxia YanGeHu Community Health Center, Yinchuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Ningxia YanGeHu Community Health Center, Yinchuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Ningxia Medical University"},{"name":"Ningxia Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/icd.2296"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091153"},{"key":"e_1_3_2_4_1","first-page":"112","article-title":"Serum gamma-glutamyltransferase and obesity: Is there a link?","volume":"72","author":"Coku V","year":"2018","unstructured":"Coku V, Shkembi X (2018) Serum gamma-glutamyltransferase and obesity: Is there a link? Medical Archives (Sarajevo, Bosnia and Herzegovina) 72: 112\u2013115.","journal-title":"Medical Archives (Sarajevo, Bosnia and Herzegovina)"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5562"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061351"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-021-05529-6"},{"key":"e_1_3_2_8_1","first-page":"202","article-title":"Gemmiger formicilis, n.gen., n.sp., an anaerobic budding bacterium from","volume":"25","author":"Gossling J","year":"1975","unstructured":"Gossling J, Moore WEC (1975) Gemmiger formicilis, n.gen., n.sp., an anaerobic budding bacterium from. Intestines 25: 202\u2013207.","journal-title":"Intestines"},{"key":"e_1_3_2_9_1","first-page":"2847","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu Z","year":"2016","unstructured":"Gu Z, Eils R, Schlesner M (2016) Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics (Oxford, England) 32: 2847\u20132849.","journal-title":"Bioinformatics (Oxford, England)"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(24)60558-3"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2024.117526"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.112563"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.732"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.04.004"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112620"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071552"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.09.034"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.11.010"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2020.111001"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191912093"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020701"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5389-5"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-1201-6"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-024-00679-2"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117401"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122346"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119626"}],"container-title":["Nutrition and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060251357979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02601060251357979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060251357979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T18:46:12Z","timestamp":1778093172000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02601060251357979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/02601060251357979"],"URL":"https:\/\/doi.org\/10.1177\/02601060251357979","relation":{},"ISSN":["0260-1060","2047-945X"],"issn-type":[{"value":"0260-1060","type":"print"},{"value":"2047-945X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}