{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:04:24Z","timestamp":1793862264272,"version":"4.6.1"},"reference-count":95,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Low serum 25-hydroxyvitamin D (25[OH]D) levels affect bone remodeling, contributing to the development and progression of knee osteoarthritis (OA).\n                    <jats:bold>Aim:<\/jats:bold>\n                    This meta-analysis aimed to estimate the prevalence of vitamin D deficiency in patients with knee OA.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A systematic search was conducted in Europe PMC, Google Scholar, Scopus, Scilit, and Web of Science for studies published until 8 August 2024 that reported the prevalence and contributing factors of hypovitaminosis D in knee OA patients. Study quality was assessed using the Newcastle\u2013Ottawa Scale. A random-effect meta-analysis with Freeman\u2013Tukey double arcsine transformation estimated the pooled prevalence of vitamin D deficiency.\n                    <jats:bold>Results:<\/jats:bold>\n                    Out of 1695 records identified, 26 studies (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20094248 patients) met the inclusion criteria. The pooled prevalence of vitamin D deficiency was 56.72% (95% CI: 46.93\u201366.25). No significant difference was observed across publication periods of 2015\u20132019 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.465) and 2020\u20132024 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.407). Patients with an average body mass index (BMI) \u226528 kg\/m\u00b2 had a higher prevalence (65.62%, 95% CI: 49.23\u201380.32) compared to those with BMI &lt;28 kg\/m\u00b2 (37.63%, 95% CI: 24.72\u201351.48). The prevalence was significantly higher in European countries (65.92%, 95% CI: 47.17\u201382.43) than in the USA (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.046). In Asia, the Middle East, and North Africa, prevalences were 60.96% (95% CI: 42.32\u201378.08) and 63.11% (95% CI: 43.8\u201380.47), respectively.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Over half of knee OA patients had vitamin D deficiency, with higher prevalence in Europe and among individuals with obesity. Targeted screening for 25(OH)D levels in knee OA patients is recommended.\n                  <\/jats:p>","DOI":"10.1177\/02601060251366001","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:46:26Z","timestamp":1755845186000},"page":"117-129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Global prevalence of vitamin D deficiency among patients with knee osteoarthritis: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6745-8848","authenticated-orcid":false,"given":"Muhammad","family":"Iqhrammullah","sequence":"first","affiliation":[{"name":"Universitas Muhammadiyah Aceh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0671-6992","authenticated-orcid":false,"given":"Juan Fransiscus","family":"Wira","sequence":"additional","affiliation":[{"name":"Universitas Jambi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Partogi","family":"Nababan","sequence":"additional","affiliation":[{"name":"Sam Ratulangi University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice Rima Christy","family":"Oey","sequence":"additional","affiliation":[{"name":"Sam Ratulangi University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seba Talat","family":"AL-Gunaid","sequence":"additional","affiliation":[{"name":"Universitas Syiah Kuala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andhika Citra","family":"Buana","sequence":"additional","affiliation":[{"name":"Dr. Cipto Mangunkusumo National Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naufal","family":"Gusti","sequence":"additional","affiliation":[{"name":"Universitas Muhammadiyah Aceh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Habiburrahman","sequence":"additional","affiliation":[{"name":"Imperial College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radi Muharris","family":"Mulyana","sequence":"additional","affiliation":[{"name":"Dr. Cipto Mangunkusumo National Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2551-9"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330025"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13114035"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/BMR-160589"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037291"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/19476035211010309"},{"issue":"1","key":"e_1_3_2_8_1","first-page":"1","article-title":"Vitamin D deficiency showed association with knee osteoarthritis in Tamil Nadu population \u2013 A pilot study","volume":"4","author":"Annamalai R","year":"2018","unstructured":"Annamalai R, Kumar AN (2018) Vitamin D deficiency showed association with knee osteoarthritis in Tamil Nadu population \u2013 A pilot study. 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