{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:29:39Z","timestamp":1777915779677,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Background:<\/jats:bold>\n Chemotherapy-induced thrombocytopenia (CIT) impacts a significant number of patients undergoing oncological treatment.\n Aim:<\/jats:bold>\n This study explored the usefulness of\n Carica papaya<\/jats:italic>\n leaf extract (CPLE) in the context of CIT, including side effect and optimal treatment dosage and duration.\n Methods:<\/jats:bold>\n Systematic literature reviews were conducted on (a) studies of patients with solid tumors and CIT who received CPLE, and (b) animal studies focused on CPLE for CIT. Risk of bias was assessed and meta-analyses were conducted.\n Results:<\/jats:bold>\n In the meta-analysis of studies on oncological patients with CIT (total\n N<\/jats:italic>\n \u2009=\u2009410, intervention\n N<\/jats:italic>\n \u2009=\u2009205), the overall effect size for CPLE administration was 2.20, 95% confidence interval (CI): 0.96\u20133.44,\n P<\/jats:italic>\n \u2009<\u20090.001. In the meta-analysis on animal models (total\n N<\/jats:italic>\n \u2009=\u200984, intervention\n N<\/jats:italic>\n \u2009=\u200942), two effect sizes were computed for two platelet measurements at different time intervals: 5.74, 95% CI: 0.32\u2009=\u200911.16,\n P<\/jats:italic>\n \u2009<\u20090.001 and 7.13, 95% CI: 4.23\u201310.02,\n P<\/jats:italic>\n \u2009<\u20090.001, respectively. CPLE dosage varied between 580 and 3300\u2005mg, with a mean of 1500\u2005mg per day. No studies reported major side effects of CPLE administration.\n Conclusion:<\/jats:bold>\n Despite heterogeneity and risk of bias concerns, the research literature available so far of both animal models and human participants suggests that CPLE might be an effective strategy for dealing with CIT. However, more rigorous research is still needed.\n <\/jats:p>","DOI":"10.1177\/02601060251367802","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T07:57:16Z","timestamp":1755763036000},"page":"1409-1420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Could\n Carica papaya<\/i>\n leaf extract impact chemotherapy-induced thrombocytopenia? A systematic review and meta-analysis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7103-9239","authenticated-orcid":false,"given":"Anca","family":"M\u00eer\u0219u-P\u0103un","sequence":"first","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1346690"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3259.ijct20173088"},{"issue":"6","key":"e_1_3_2_4_1","first-page":"22","article-title":"Effect of Carica papaya leaf extract capsule on platelet count in patients of dengue fever with thrombocytopenia","volume":"64","author":"Gadhwal AK","year":"2016","unstructured":"Gadhwal AK, Ankit BS, Chahar C, et al. (2016) Effect of Carica papaya leaf extract capsule on platelet count in patients of dengue fever with thrombocytopenia. The Journal of the Association of Physicians of India 64(6): 22\u201326.","journal-title":"The Journal of the Association of Physicians of India"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00616-3"},{"key":"e_1_3_2_6_1","doi-asserted-by":"crossref","unstructured":"Gaspari M Allegra S Bettonte G et al. (2024) Phytotherapy use to treat chemotherapy-related side effects in lung cancer patients [Preprint]. 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International Journal of Clinical and Experimental Medicine 10(2): 3752\u20133756.","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07311-6"},{"issue":"6","key":"e_1_3_2_10_1","first-page":"2651","article-title":"Anti myelosuppressant and hematopoietic activities of ethanolic fraction obtained from seeds of Carica papaya L","volume":"33","author":"Ishaque A","year":"2020","unstructured":"Ishaque A, et al. (2020) Anti myelosuppressant and hematopoietic activities of ethanolic fraction obtained from seeds of Carica papaya L. 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Bulletin of Pharmaceutical Sciences 47(2): 917\u2013926.","journal-title":"Bulletin of Pharmaceutical Sciences"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.5958\/0976-5506.2017.00431.4"},{"issue":"4","key":"e_1_3_2_22_1","first-page":"62","article-title":"Evaluation of the efficacy of Carica papaya leaf extract on platelet counts in dengue patients","volume":"11","author":"Solanki SG","year":"2020","unstructured":"Solanki SG, Trivedi P (2020) Evaluation of the efficacy of Carica papaya leaf extract on platelet counts in dengue patients. 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