{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:14:59Z","timestamp":1788520499477,"version":"build-2803163510"},"reference-count":62,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Intermittent fasting (IF) is increasingly adopted for weight and metabolic health management, yet its impact on lipid profile and physical performance in young and middle-aged men remains unclear.\n                    <jats:bold>Aim:<\/jats:bold>\n                    The present study examined the effect of a five-month (IF) on body composition, lipid profile, and physical performance.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A randomized controlled trial was conducted to evaluate the impact of this eating pattern. Forty active male participants were divided into two age groups (a young group from 23 to 28 years and a middle-aged group from 46 to 59 years) and then randomly assigned to experimental (young experimental group (YE), middle-aged experimental group (ME)) or control groups (young control group, middle-aged control group). Before and after the five-month (IF) intervention (4 days per week), all participants performed the Running-based Anaerobic Sprint and the Test Blood for the determination of lipids profile.\n                    <jats:bold>Results:<\/jats:bold>\n                    Both young (YE) and middle-aged (ME) experimental groups showed significant reductions in weight (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012 for YE and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.011 for ME), body mass index (BMI) (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.011 for YE and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012 for ME) and fat-free mass (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004 for YE and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.043 for ME) compared to control groups. Analysis of variance (ANOVA) revealed significant main effects of time and group for weight (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012), BMI (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.038), and fat-free mass (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.023;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.037), with significant time\u2009\u00d7\u2009group interaction for weight (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.017) and trends for BMI (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.048) and fat-free mass (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.07); no significant effects were observed for body fat percentage (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). In addition, our results showed that (IF) was associated with significant decrease in total cholesterol (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004 for YE and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.0024 for ME) and high-density lipoprotein (HDL) levels (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.004 for YE and\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.009 for ME) in both experimental groups. Low-density lipoprotein decreased significantly only in the young IF group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.041). However, IF did not affect triglyceride levels or physical performance. ANOVA revealed a significant interaction between time and group for HDL (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with greater reductions in middle-aged participants, and a significant group effect for triglycerides (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), which were higher in middle-aged groups at both time points.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    These results suggest that while IF can positively influence body composition and is associated with selective changes in lipid profiles, its effects on triglycerides and physical performance may be limited. These findings underscore the need for further research to explore the long-term metabolic implications of IF, as well as potential age-related differences in response to fasting regimens.\n                  <\/jats:p>","DOI":"10.1177\/02601060251385278","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:41:13Z","timestamp":1760553673000},"page":"1603-1618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The influence of intermittent fasting on body metrics, lipid profile, and physical performance in young and middle-aged men"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-8061","authenticated-orcid":false,"given":"Maha","family":"Gasmi","sequence":"first","affiliation":[{"name":"Higher Institute of Sport and Physical Education of Ksar Said"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-3976","authenticated-orcid":false,"given":"Aymen","family":"Hawani","sequence":"additional","affiliation":[{"name":"Higher Institute of Sport and Physical Education of Ksar Said"},{"name":"Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Ben Chikha","sequence":"additional","affiliation":[{"name":"Higher Institute of Sport and Physical Education of Ksar Said"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Eken","sequence":"additional","affiliation":[{"name":"Inonu University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-3286","authenticated-orcid":false,"given":"Santo","family":"Marsigliante","sequence":"additional","affiliation":[{"name":"University of Salento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Muscella","sequence":"additional","affiliation":[{"name":"University of Salento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3994-4054","authenticated-orcid":false,"given":"Riadh","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Higher Institute of Sport and Physical Education of Ksar Said"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237922"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1555935"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29245955"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084739"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz962"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273230"},{"key":"e_1_3_3_8_1","doi-asserted-by":"crossref","unstructured":"Carey VJ Bishop L Laranjo N et al. 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