{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:21:04Z","timestamp":1788445264241,"version":"build-2803163510"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood anemia is a very common problem in India, out of which more than one-third is attributed to vitamin B12 deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To follow up on a girl with recurrent anemia who was later diagnosed with hereditary intrinsic factor deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An eight-year-old girl presented with recurrent anemia, easy fatigability, poor appetite, and abdominal pain for one month. The hemoglobin was 4.3\u2005g\/dL, and the peripheral smear showed a dimorphic picture. Serum vitamin B12 was severely low at &lt;50\u2005pg\/mL. After a packed red blood cell transfusion, she was advised to take oral vitamin B12 and iron supplements. Her symptoms and vitamin B12 levels did not improve on follow-up, which led to suspicion of a congenital intrinsic factor deficiency (proven by whole exome sequencing). The child is currently doing well on monthly vitamin B12 injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>This case highlights the importance of considering rare inherited causes in a child with recurrent severe anemia, even in regions where nutritional deficiencies are common.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261444561","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:29:32Z","timestamp":1776781772000},"page":"1125-1130","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Megaloblastic anemia due to hereditary intrinsic factor deficiency presenting as recurrent anemia in a young girl\u2014a case report"],"prefix":"10.1177","volume":"32","author":[{"given":"Renuka Sri Ananta Lakshmi","family":"Motamarri","sequence":"first","affiliation":[{"name":"Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vigneshwaran","family":"Muthuvel","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravani","family":"Madhileti","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8828-4039","authenticated-orcid":false,"given":"Ramya","family":"Srinivasa Rangan","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-0070","authenticated-orcid":false,"given":"Dhandapany","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1968.tb02452.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2016.00038"},{"key":"e_1_3_3_4_1","first-page":"2942","volume-title":"Nelson Textbook of Pediatrics","author":"Courtney DT","year":"2020","unstructured":"Courtney DT (2020) Megaloblastic anemias. In: Kliegman RM, et al. (eds.) Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier, pp. 2942\u20132944.","edition":"21"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182242124"},{"key":"e_1_3_3_6_1","unstructured":"India National Family Health Survey (NFHS-4) 2015-16 [FR339]. Available at: https:\/\/healthnutritionindia.in\/static_files\/nfhs4\/nfhs4_report.pdf (accessed 28 March 2026)."},{"key":"e_1_3_3_7_1","unstructured":"Orphanet (2011). Congenital intrinsic factor deficiency. Available at: https:\/\/www.orpha.net\/en\/disease\/detail\/332 (accessed 30 March 2026)."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-020-01158-z"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30094-8"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15133026"},{"key":"e_1_3_3_11_1","doi-asserted-by":"crossref","unstructured":"Sturm AC Baack EC Armstrong MB et al. (2012) Hereditary intrinsic factor deficiency in Chaldeans. JIMD Reports 7 13\u201318.","DOI":"10.1007\/8904_2012_133"},{"key":"e_1_3_3_12_1","doi-asserted-by":"crossref","unstructured":"Zittoun J Leger J Marquet J et al. (1988) Combined congenital deficiencies of intrinsic factor and R binder. Blood 72(3): 940\u2013943.","DOI":"10.1182\/blood.V72.3.940.940"}],"container-title":["Nutrition and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060261444561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02601060261444561","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02601060261444561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:09:32Z","timestamp":1788444572000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02601060261444561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/02601060261444561"],"URL":"https:\/\/doi.org\/10.1177\/02601060261444561","relation":{},"ISSN":["0260-1060","2047-945X"],"issn-type":[{"value":"0260-1060","type":"print"},{"value":"2047-945X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}