{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:23:53Z","timestamp":1789064633220,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) continues to rise globally, highlighting the need for effective and sustainable dietary strategies. Intermittent fasting (IF) and ketogenic diets have been associated with metabolic adaptations such as enhanced fat oxidation, ketone body production, and improved insulin sensitivity; however, evidence on their combined implementation in clinical settings remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the associations of three dietary strategies\u2014IF combined with a ketogenic diet (IF\u2009+\u2009KD), a hypocaloric diet (HD), and a control group (CG)\u2014with anthropometric, metabolic, behavioral, and quality-of-life outcomes in adults with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 12-week controlled, parallel-group clinical study was conducted in 30 adults with T2DM allocated to IF\u2009+\u2009KD (n\u2009=\u200910), HD (n\u2009=\u200910), or CG (n\u2009=\u200910). The IF\u2009+\u2009KD group followed a structured 16:8 IF protocol combined with a ketogenic diet, while the HD group received an individualized energy-restricted diet. Anthropometric, biochemical, physical activity, and quality-of-life measures were assessed at baseline and week 12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reductions were observed in body weight, body mass index, waist circumference, and body fat percentage (all p\u2009&lt;\u20090.05). HbA1c decreased in both IF\u2009+\u2009KD and HD groups, and total cholesterol was reduced without adverse changes in renal function. Physical activity and quality-of-life scores improved in intervention groups, with minimal variation in the CG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IF\u2009+\u2009KD and HD were associated with short-term improvements in metabolic and anthropometric outcomes in adults with T2DM. Findings provide real-world evidence on combined dietary strategies and should be interpreted within the context of a non-randomized design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261446178","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:35:32Z","timestamp":1778250932000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of intermittent fasting combined with a ketogenic diet versus a hypocaloric diet on metabolic outcomes in adults with type 2 diabetes mellitus: A controlled clinical study"],"prefix":"10.1177","author":[{"given":"Edgar","family":"Barrionuevo-Burgos","sequence":"first","affiliation":[{"name":"Iberoamerican University Foundation (FUNIBER)"},{"name":"Department of Nutrition, Pure Corpore Clinic, Castelldefels, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Marina","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto Venezolano de Investigaciones Cient\u00edficas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Familiar y Comunitaria Socu\u00e9llamos"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-9965","authenticated-orcid":false,"given":"Andrea","family":"Arregu\u00edn-Coronado","sequence":"additional","affiliation":[{"name":"Autonomous University of San Luis Potos\u00ed"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.596787"},{"issue":"1","key":"e_1_3_3_3_1","article-title":"Comprehensive medical evaluation and assessment of comorbidities: Standards of medical care in diabetes\u20142023","volume":"46","author":"American Diabetes Association","year":"2023","unstructured":"American Diabetes Association (2023) Comprehensive medical evaluation and assessment of comorbidities: Standards of medical care in diabetes\u20142023. 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