{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:15:14Z","timestamp":1788520514452,"version":"build-2803163510"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Euro-Pharma s.r.l."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"published-print":{"date-parts":[[2026,9]]},"abstract":"\n Background<\/jats:title>\n Gastroesophageal reflux disease (GERD) is associated with epithelial injury and inflammation of the upper gastrointestinal tract. Long-term pharmacological therapies may present limitations, encouraging interest in complementary approaches.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n This study evaluated the\n in vitro<\/jats:italic>\n wound healing and anti-inflammatory activity of the multicomponent gel food supplement Reflus Gel\n \u00ae<\/jats:sup>\n (RG), formulated for gastric acidity management.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Wound healing was assessed using a scratch assay on fully confluent Caco-2 cells, while anti-inflammatory activity was evaluated by measuring interleukin (IL)-1\u03b2, IL-6, and tumour necrosis factor (TNF)-\u03b1 release in lipopolysaccharide-stimulated THP-1-derived macrophages by enzyme-linked immunosorbent assay.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n RG enhanced wound closure at 24 and 48\u2005h compared with untreated control (\n p<\/jats:italic>\n \u2009<\u20090.0001) and reduced IL-1\u03b2 (\n p<\/jats:italic>\n \u2009<\u20090.01), IL-6 and TNF-\u03b1 (\n p<\/jats:italic>\n \u2009<\u20090.0001) secretion in stimulated macrophages.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings indicate that RG promotes cell migration and modulates inflammatory responses\n in vitro<\/jats:italic>\n , suggesting a potential role as a complementary strategy in GERD management.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/02601060261452076","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:45:43Z","timestamp":1779367543000},"page":"1437-1442","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["In vitro<\/i>\n wound healing and anti-inflammatory properties of a multicomponent gel food supplement: Preclinical evidence for a complementary approach in gastroesophageal reflux disease management"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7181-8536","authenticated-orcid":false,"given":"Marta","family":"Pulcini","sequence":"first","affiliation":[{"name":"Biosolving S.r.l., Roseto degli Abruzzi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Mori","sequence":"additional","affiliation":[{"name":"Biosolving S.r.l., Roseto degli Abruzzi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G","family":"Marini","sequence":"additional","affiliation":[{"name":"Biosolving S.r.l., Roseto degli Abruzzi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Massaccesi","sequence":"additional","affiliation":[{"name":"Biosolving S.r.l., Roseto degli Abruzzi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.11.001"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.51847\/Zab2Kbi6A9"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030290"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11152250"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43939-025-00317-4"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00287-w"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-019-4672-5"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16121531"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17061069"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501327211046736"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10720-4"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071468"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-025-01490-6"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2025.01.022"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14022"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0334396"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.065"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.70164"},{"issue":"35","key":"e_1_3_3_20_1","article-title":"Advances in polymeric nanoparticles for oral drug delivery: mechanisms, challenges, emerging trends, and preclinical to clinical perspectives","volume":"16","author":"Zehravi M","year":"2025","unstructured":"Zehravi M, Khan SL, Gupta JK, et al. (2025) Advances in polymeric nanoparticles for oral drug delivery: mechanisms, challenges, emerging trends, and preclinical to clinical perspectives. 3 Biotech 16(35). DOI: 10.1007\/s13205-025-04659-x.","journal-title":"3 Biotech"},{"key":"e_1_3_3_21_1","article-title":"Multidimensional mechanisms and therapies underlying gastroesophageal reflux disease: focus on immunity, signaling pathways, and the microbiota-gut-brain axis","volume":"16","author":"Zheng J","year":"2025","unstructured":"Zheng J, Tao L (2025) Multidimensional mechanisms and therapies underlying gastroesophageal reflux disease: focus on immunity, signaling pathways, and the microbiota-gut-brain axis. Frontiers in Immunology 16. 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