{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:24:31Z","timestamp":1790965471731,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D deficiency is prevalent among pediatric patients with sickle cell disease (SCD) and may be associated with acute clinical complications. Despite its potential impact, the effects of this deficiency in this population are not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims\/Objectives<\/jats:title>\n                    <jats:p>This study aims to review the current literature on vitamin D deficiency in children with SCD, focusing on its clinical and laboratory outcomes, and to explore the potential benefits of vitamin D supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Methodology<\/jats:title>\n                    <jats:p>A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Searches were performed across five databases\u2014MEDLINE, LILACS, Cochrane, EMBASE, and Scientific Electronic Library Online. From an initial pool of 497 articles, 12 met the inclusion criteria and were included in the final analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\/Findings<\/jats:title>\n                    <jats:p>The review identified several clinical and laboratory outcomes associated with vitamin D deficiency in pediatric SCD patients. Vaso-occlusive crises were the most commonly reported clinical outcome, appearing in 25% of the studies. Similarly, hospitalizations were noted in a quarter of the reviewed articles. Laboratory findings most frequently included anemia and hemolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency in pediatric sickle cell patients is linked to worse clinical and laboratory outcomes, including increased crises and hospitalizations. Supplementation may help, but evidence is insufficient; further studies are needed to guide recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261462433","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:05:02Z","timestamp":1782299102000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A systematic review on clinical and laboratory effects of vitamin D deficiency in children with sickle cell disease"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-3427","authenticated-orcid":false,"given":"Thiago de Souza","family":"Vilela","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"},{"name":"Instituto PENSI de Pesquisa\u2014Sabar\u00e1 Hospital Infantil, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-3215","authenticated-orcid":false,"given":"Mauro","family":"Fisberg","sequence":"additional","affiliation":[{"name":"Instituto PENSI de Pesquisa\u2014Sabar\u00e1 Hospital Infantil, S\u00e3o Paulo, Brazil"},{"name":"Department of Pediatrics\u2014Division of Pediatric Nutrology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-6576","authenticated-orcid":false,"given":"Gerson","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Universidad de Santiago de Chile"},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-6904","authenticated-orcid":false,"given":"Josefina Aparecida","family":"Pellegrini Braga","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"issue":"14","key":"e_1_3_3_2_1","first-page":"5043","article-title":"Comparative effectiveness of adding omega-3 or vitamin D to standard therapy in preventing and treating episodes of painful crisis in pediatric sickle cell patients","volume":"26","author":"Abdelhalim SM","year":"2022","unstructured":"Abdelhalim SM, Murphy JE, Meabed MH, et al. (2022) Comparative effectiveness of adding omega-3 or vitamin D to standard therapy in preventing and treating episodes of painful crisis in pediatric sickle cell patients. 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