{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T02:26:05Z","timestamp":1786847165818,"version":"build-2736575974"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While global nutrition policies increasingly promote plant-based diets for environmental sustainability, this approach may implicitly assume biological homogeneity and overlook interindividual genetic variability in nutrient metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This review evaluates potential molecular bottlenecks and genetic variations that may influence individual adaptation to plant-based dietary patterns, based on recent literature in nutrigenetics and micronutrient metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peer-reviewed literature published primarily between 2015 and 2025 was searched across PubMed, Web of Science, and Scopus using nutrigenetics- and plant-based nutrition-related terms; Google Scholar was additionally consulted for supplementary citation tracking. Foundational studies were included where mechanistically relevant. Studies lacking genotypic data, in vitro models without clinical relevance, and non-English publications were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      Current evidence suggests that the conversion efficiency of plant-derived precursors into biologically active forms differs according to polymorphisms in genes including fatty acid desaturases (\n                      <jats:italic toggle=\"yes\">FADS1\/FADS2<\/jats:italic>\n                      ), beta-carotene oxygenase-1 (\n                      <jats:italic toggle=\"yes\">BCO1<\/jats:italic>\n                      ), and phosphatidylethanolamine N-methyltransferase (\n                      <jats:italic toggle=\"yes\">PEMT<\/jats:italic>\n                      ). Moreover, phytate-mediated constraints and variations affecting mineral absorption\u2014transmembrane serine protease 6 (\n                      <jats:italic toggle=\"yes\">TMPRSS6<\/jats:italic>\n                      ) and solute carrier family 39 member 4 (\n                      <jats:italic toggle=\"yes\">SLC39A4<\/jats:italic>\n                      )\u2014and vitamin B12 transport\u2014fucosyltransferase-2 (\n                      <jats:italic toggle=\"yes\">FUT2<\/jats:italic>\n                      ) and transcobalamin-2 (\n                      <jats:italic toggle=\"yes\">TCN2<\/jats:italic>\n                      )\u2014may increase susceptibility to subclinical micronutrient insufficiencies in genetically predisposed individuals. Although many associations reach statistical significance, their clinical impact varies across populations and depends on the overall dietary context. These genetic influences are not deterministic and may potentially be mitigated through targeted dietary planning and personalized supplementation. Precision nutrition frameworks incorporating genetic variability may improve dietary personalization; however, future large-scale longitudinal trials are required before these findings can address consensus clinical guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261478364","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:27:16Z","timestamp":1786627636000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Are sustainable plant-based diets suitable for all? A nutrigenetic perspective"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6873-9983","authenticated-orcid":false,"given":"Eren","family":"Terzio\u011flu","sequence":"first","affiliation":[{"name":"Istanbul Medipol University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-349X","authenticated-orcid":false,"given":"Indrani","family":"Kalkan","sequence":"additional","affiliation":[{"name":"Istanbul Medipol University"},{"name":"Istanbul Medipol University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-023-03690-7"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2016.07.002"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15120758"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2018.04.015"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1538505"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100322"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17020242"},{"issue":"1","key":"e_1_3_3_9_1","first-page":"192","article-title":"Carotenoid metabolic (BCO1) polymorphisms and personal behaviors modify the risk of coronary atherosclerosis: A nested case-control study in Han Chinese with dyslipidaemia (2013\u20132016)","volume":"28","author":"Cai X","year":"2019","unstructured":"Cai X, Lian F, Kong Y, et al. 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