{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:52:28Z","timestamp":1791039148081,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2023\u201340"],"award-info":[{"award-number":["lzujbky-2023\u201340"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gansu Province Science Foundation for Youths","award":["21JR7RA507"],"award-info":[{"award-number":["21JR7RA507"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003525"],"award-info":[{"award-number":["82003525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous research on multimorbidity focused on patterns, prevalence, and correlation and studies on famine have primarily focused on single diseases, with limited research on its effect on multimorbidity, especially in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Our study aimed to examine the association between famine exposure and the risk of multimorbidity through a cross-sectional survey in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 1580 community-dwelling older people were included in this study. Famine exposure was classified as nonexposed, toddlers exposed (1\u20133 years old exposed), preschool-age children exposed (4\u20136 years old exposed), school-age children exposed (7\u201313 years old exposed), adolescent exposed (14 to 19 years old exposed), adult exposed (20 years and older exposed). Multimorbidity was defined as \u201cthe co-occurrence of at least two chronic conditions in the same individual\u201d based on the data of 39 common diseases. The associations were presented using adjusted odds ratio (aOR) with corresponding 95% confidence intervals (CI), and statistical significance was determined at\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicated that famine exposure substantially elevated the risk of multimorbidity. Compared with the nonexposed group, the risks of Cardiometabolic and Complex\/multisystem multimorbidity were increased in the preschool (OR: 2.03, 95%CI: 1.01, 4.08) and school-age exposed groups (OR: 2.27, 95%CI: 1.06, 4.88), respectively. Specifically, early-life exposure to Chinese famine was associated with an increased risk of developing high blood pressure (OR: 1.46, 95%CI: 1.00\u20132.11), chronic pulmonary diseases\/asthma (OR: 1.78, 95%CI: 1.02\u20133.12), fractures (OR: 1.865, 95%CI:1.14, 3.04), and cataracts (OR: 2.26, 95%CI:1.22, 4.19) in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Individuals exposed to famine in early childhood, especially during preschool and school-age years, significantly increased their risk of multimorbidity in adulthood. These findings highlight the need for targeted health interventions and long-term disease prevention strategies for individuals who experienced early-life nutritional deprivation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261489297","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:31:56Z","timestamp":1790771516000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Famine exposure in childhood and multimorbidity risk in older adults"],"prefix":"10.1177","author":[{"given":"Qianwen","family":"Yang","sequence":"first","affiliation":[{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"He","sequence":"additional","affiliation":[{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoMing","family":"Liu","sequence":"additional","affiliation":[{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-0324","authenticated-orcid":false,"given":"Lipeng","family":"Jing","sequence":"additional","affiliation":[{"name":"Lanzhou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-022-01815-w"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1081518"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01055"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-02793-2"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.104147"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-034441"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00568-5"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.973753"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-51"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156609"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1474-7"},{"key":"e_1_3_3_13_1","first-page":"205","article-title":"Global multimorbidity patterns: A cross-sectional, population-based, multi-country study","volume":"71","author":"Garin N","year":"2016","unstructured":"Garin N, Koyanagi A, Chatterji S, et al. 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