{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:02:21Z","timestamp":1790776941525,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nutr Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility, but evidence regarding coenzyme Q10 (CoQ10) supplementation remains limited and inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate associations between pre-IVF CoQ10 supplementation and embryological and reproductive outcomes in women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort included 154 women receiving CoQ10 (100\u2005mg\/day for four weeks before IVF;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200975) or no CoQ10 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200979), as documented in medical records. Embryological and reproductive outcomes were compared, and logistic regression analyses adjusted for age and BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      Median age was 27 years (IQR, 24\u201330) in both groups. Body weight was higher with CoQ10 [74 (64\u201386) vs. 68 (60\u201380) kg;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.029], whereas BMI did not differ. CoQ10 recipients had higher median MII oocyte counts [18 (12\u201322) vs. 12 (10\u201316)], and 2PN oocyte counts [15 (11\u201320) vs. 10 (8\u201313); both\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001]. Both medians were 50.0% higher with CoQ10. Pregnancy occurrence was 56.0% versus 30.4% (OR\u2009=\u20092.92, 95% CI: 1.50\u20135.65), clinical pregnancy was 46.7% versus 16.5% (OR\u2009=\u20094.44, 95% CI: 2.10\u20139.39), and live birth was 30.7% versus 6.3% (OR\u2009=\u20096.55, 95% CI: 2.34\u201318.34). Absolute between-group differences were 25.6, 30.2, and 24.4 percentage points, respectively. After adjustment, CoQ10 remained associated with pregnancy occurrence (aOR\u2009=\u20093.01, 95% CI: 1.54\u20135.90), clinical pregnancy (aOR\u2009=\u20094.82, 95% CI: 2.24\u201310.36), and live birth (aOR\u2009=\u20096.86, 95% CI: 2.42\u201319.47; all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\u2264\u20090.001). Pre-IVF CoQ10 supplementation was associated with better embryological and reproductive outcomes in this cohort. Given the retrospective, non-randomized design, prospective randomized trials are required to confirm efficacy and mechanisms. Selection bias, confounding by indication, and residual confounding therefore cannot be excluded.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02601060261491431","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:35:28Z","timestamp":1790609728000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of coenzyme Q10 supplementation on in vitro fertilization outcomes in infertile patients with polycystic ovary syndrome"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-5338","authenticated-orcid":false,"given":"Latife","family":"Mutlu \u00d6zmen","sequence":"first","affiliation":[{"name":"Nuh Naci Yazgan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-4133","authenticated-orcid":false,"given":"Neriman","family":"\u0130nan\u00e7","sequence":"additional","affiliation":[{"name":"Nuh Naci Yazgan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-1364","authenticated-orcid":false,"given":"Ahmet Emin","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Erciyes Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5459-9424","authenticated-orcid":false,"given":"Asl\u0131 Gizem","family":"\u00c7apar","sequence":"additional","affiliation":[{"name":"Nuh Naci Yazgan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001732"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1643287"},{"key":"e_1_3_3_4_1","unstructured":"Ercan P (2009) Determination of in vitro bioavailability of coenzyme Q10 in some foods and foods enriched with different coenzyme Q10 preparations. Master\u2019s thesis Ege University Graduate School of Natural and Applied Sciences \u0130zmir Turkey."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01906-3"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1137095"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.7299"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1633166"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.35440\/hutfd.1255531"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.5336\/jcog.2019-66096"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2389469"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023811"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.04.002"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.11.008"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv029"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa051"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2026.105734"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-01043-9"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179541"},{"key":"e_1_3_3_20_1","article-title":"Antioxidants for female subfertility","volume":"8","author":"Showell MG","year":"2020","unstructured":"Showell MG, Mackenzie-Proctor R, Jordan V (2020) Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 8: CD007807.","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead156"},{"key":"e_1_3_3_22_1","volume-title":"Diyabet Tan\u0131 ve Tedavi Rehberi 2021. G\u00fcncellenmi\u015f 10. bask\u0131","author":"T\u00fcrkiye Diyabet Vakf\u0131","year":"2021","unstructured":"T\u00fcrkiye Diyabet Vakf\u0131 (2021) Diyabet Tan\u0131 ve Tedavi Rehberi 2021. G\u00fcncellenmi\u015f 10. bask\u0131. T\u00fcrkiye Diyabet Vakf\u0131. 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